High Expression of SOD2 Protein Is a Strong Prognostic Factor for Stage IIIB Squamous Cell Cervical Carcinoma

Autor(es)

Talarico, Maria Cecilia Ramiro ^[1] ; Nunes, Rafaella Almeida Lima ^[2] ; Silva, Gabriela Avila Fernandes ^[2] ; Costa, Larissa Bastos Eloy da ^[3] ; Cardoso, Marcella Regina ^[1] ; Esteves, Sergio Carlos Barros ^[4] ; Zanatta Sarian, Luis Otavio ^[1] ; Zeferino, Luiz Carlos ^[1] ; Termini, Lara ^[2]

Afiliação do(s) autor(es)

^[1] State Univ Campinas UNICAMP Univ Estadual Campina, Dept Obstet & Gynecol, Div Gynecol & Breast Oncol, Sch Med Sci, BR-13081970 Campinas, SP - Brazil

^[2] Univ Sao Paulo, Ctr Invest Translac Oncol, Inst Canc Estado Sao Paulo, Hosp Clin, Fac Med, BR-05403911 Sao Paulo - Brazil

^[3] State Univ Campinas UNICAMP Univ Estadual Campina, Dept Pathol, BR-13083887 Campinas, SP - Brazil

^[4] State Univ Campinas UNICAMP Univ Estadual Campina, Womens Hosp Prof Doutor Jose Aristodemo Pinotti, Dept Radiotherapy, Div Gynecol & Breast Oncol, Ctr Atencao Integral S, BR-13083881 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ANTIOXIDANTS; v. 10, n. 5 MAY 2021.
• Citações Web of Science: 0

Resumo

High superoxide dismutase 2 (SOD2) expression is associated with a poor prognosis at many cancer sites, the presence of metastases, and more advanced cervical cancer. This study aims to determine whether SOD2 protein expression is associated with the prognosis of stage IIIB cervical carcinoma. Methods: sixty-three patients with stage IIIB squamous cell cervical carcinoma were included. The evaluation of SOD2 expression by immunohistochemistry was based on a positive cell ratio score and the staining intensity score. Taking disease recurrence and death as endpoints, receiver operating characteristic curves were used to discriminate between high and low SOD2 expression. Results: high SOD2 expression was associated with recurrence (p = 0.001), distant recurrence (p = 0.002), and death (p = 0.005). A multivariate analysis showed that patients with high SOD2 expression had a threefold increased risk for recurrence (HR = 3.16; 1.33-7.51) and death (HR = 2.98; 1.20-7.40) compared with patients who had low SOD2 expression. Patients with high SOD2 expression had shorter disease-free survival (p = 0.001) and overall survival (p = 0.003) than patients with low SOD2 expression. Conclusion: high SOD2 expression is a strong prognostic factor for stage IIIB squamous cell carcinoma of the cervix and could be used as a prognostic marker in women with cervical carcinoma. (AU)

• Processo FAPESP: 12/16059-1 - Avaliação da expressão das proteínas calicreína humana e superóxido desmutase-2 como biomarcadores de neoplasia do colo do útero
• Beneficiário: Luiz Carlos Zeferino
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 10/07739-3 - Relação entre a expressão das proteínas calicreína (hK7) e superóxido desmutase 2 (SOD2) com os tipos de papilomavírus humano (HPV), tipo histológico e severidade da neoplasia cervical
• Beneficiário: Luiz Carlos Zeferino
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/26573-2 - Estudo do papel da proteína superóxido dismutase 2 (sod2) no processo de transformação celular mediado por hpv
• Beneficiário: Lara Termini
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 08/57889-1 - Instituto de Ciência e Tecnologia para o Estudo das Doenças Associadas ao Papilomavírus
• Beneficiário: Luisa Lina Villa
• Modalidade de apoio: Auxílio à Pesquisa - Temático