| Texto completo | |
| Autor(es): Mostrar menos - |
Casaro, Mateus B.
[1]
;
Thomas, Andrew M.
[2, 3, 4]
;
Mendes, Eduardo
[1]
;
Fukumori, Claudio
[1]
;
Ribeiro, Willian R.
[1]
;
Oliveira, Fernando A.
[5]
;
Crisma, Amanda R.
[6]
;
Murata, Gilson M.
[7]
;
Bizzarro, Bruna
[8]
;
Sa-Nunes, Anderson
[8]
;
Setubal, Joao C.
[2]
;
Mayer, Marcia P. A.
[9]
;
Martins, Flaviano S.
[10]
;
Vieira, Angelica T.
[11]
;
Antiorio, Ana T. F. B.
[12]
;
Tavares-de-Lima, Wothan
[13]
;
Camara, Niels O. S.
[8]
;
Curi, Rui
[14]
;
Dias-Neto, Emmanuel
[4, 15]
;
Ferreira, Caroline M.
[1]
Número total de Autores: 20
|
| Afiliação do(s) autor(es): Mostrar menos - | [1] Univ Fed Sao Paulo, Inst Environm Chem & Pharmaceut Sci, Dept Pharmaceut Sci, R Sao Nicolau 210, BR-0991303 Diadema, SP - Brazil
[2] Univ Sao Paulo, Inst Chem, Dept Biochem, Sao Paulo - Brazil
[3] Univ Trento, Dept CIBIO, Trento - Italy
[4] CIPE AC Camargo Canc Ctr, Med Genom Lab, Sao Paulo - Brazil
[5] Fed Univ ABC UFABC, Ctr Math Comp & Cognit CMCC, Sao Bernardo Do Campo, SP - Brazil
[6] Univ Fed Parana, Dept Clin Anal, Curitiba, Parana - Brazil
[7] Univ Sao Paulo, Dept Clin Med, Fac Med, BR-01246903 Sao Paulo - Brazil
[8] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Sao Paulo - Brazil
[9] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo, SP - Brazil
[10] Univ Fed Minas Gerais, Inst Biol Sci, Dept Microbiol, Belo Horizonte, MG - Brazil
[11] Univ Fed Minas Gerais, Biol Sci Inst, Dept Biochem & Immunol, Belo Horizonte, MG - Brazil
[12] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, Sao Paulo - Brazil
[13] Univ Sao Paulo, Inst Biomed Sci 1, Dept Pharmacol, Sao Paulo - Brazil
[14] Univ Cruzeiro Sul, Interdisciplinary Post Grad Program Hlth Sci, Sao Paulo - Brazil
[15] Univ Sao Paulo, Inst Psychiat, Sch Med, Lab Neurosci LIM 27, Sao Paulo - Brazil
Número total de Afiliações: 15
|
| Tipo de documento: | Artigo Científico |
| Fonte: | MICROBIOME; v. 9, n. 1 JUN 10 2021. |
| Citações Web of Science: | 1 |
| Resumo | |
The phenotypes of allergic airway diseases are influenced by the interplay between host genetics and the gut microbiota, which may be modulated by probiotics. We investigated the probiotic effects on allergic inflammation in NJ and C57BU6 mice. C57BU6 mice had increased gut microbiota diversity compared to NJ mice at baseline. Acetate producer probiotics differentially modulated and altered the genus abundance of specific bacteria, such as Akkermansia and Allistipes, in mouse strains. We induced airway inflammation followed by probiotic treatment and found that only A/J mice exhibited decreased inflammation, and the beneficial effects of probiotics in NJ mice were partially due to acetate production. To understand the relevance of microbial composition colonization in the development of allergic diseases, we implanted female C57BU6 mice with NJ embryos to naturally modulate the microbial composition of NJ mice, which increased gut microbiota diversity and reduced eosinophilic inflammation in A/J. These data demonstrate the central importance of microbiota to allergic phenotype severity. (AU) | |
| Processo FAPESP: | 12/50410-8 - Efeito dos ácidos graxos de cadeia curta produzidos por bactérias probióticas na profilaxia e tratamento da inflamação alérgica das vias aéreas |
| Beneficiário: | Caroline Marcantonio Ferreira |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 16/13496-2 - Papel da administração de simbióticos no período perinatal na asma alérgica experimental da prole |
| Beneficiário: | Mateus Campos Casaro |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |
| Processo FAPESP: | 19/12324-1 - Probiótico como uma ferramenta terapêutica no eixo pele-pulmão-intestino |
| Beneficiário: | Caroline Marcantonio Ferreira |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |