High Heterogeneity of Echoviruses in Brazilian Children with Acute Gastroenteritis

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Foro Ramos, Endrya do Socorro ^[1] ; Rosa, Ulisses Alves ^[1] ; Ribeiro, Geovani de Oliveira ^[1] ; Villanova, Fabiola ^[1] ; de Padua Milagres, Flavio Augusto ^{[2, 3]} ; Brustulin, Rafael ^[2] ; Morais, Vanessa dos Santos ^[4] ; Bertanhe, Mayara ^[4] ; Marcatti, Roberta ^[4] ; Araujo, Emerson Luiz Lima ^[5] ; Witkin, Steven S. ^{[6, 4]} ; Delwart, Eric ^{[7, 8]} ; Luchs, Adriana ^[9] ; da Costa, Antonio Charlys ^[4] ; Leal, Elcio ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Para, Inst Ciencias Biol, Lab Diversidade Viral, BR-66075000 Belem, Para - Brazil

^[2] Secretaria Saude Tocantins, BR-77453000 Palmas, Tocantins - Brazil

^[3] Lab Cent Saude Publ Tocantins LACEN TO, BR-77016330 Palmas, Tocantins - Brazil

^[4] Univ Sao Paulo, Fac Med, Inst Med Trop, Dept Molestias Infecciosas & Parasitarias, BR-05403000 Sao Paulo - Brazil

^[5] Minist Hlth CGLAB DAEVS SVS MS, Gen Coordinat Publ Hlth Labs Strateg Articulat, Dept Hlth Surveillance Secretariat, BR-70719040 Brasilia, DF - Brazil

^[6] Weill Cornell Med, Dept Obstet & Gynecol, 1300 York Ave, New York, NY 10065 - USA

^[7] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 - USA

^[8] Vitalant Res Inst, 270 Masonic Ave, San Francisco, CA 94143 - USA

^[9] Adolfo Lutz Inst, Ctr Virol, Lab Doencas Enter, BR-01246000 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Viruses-Basel; v. 13, n. 4 APR 2021.
• Citações Web of Science: 0

Resumo

Echoviruses (E) are a diverse group of viruses responsible for various pathological conditions in humans including aseptic meningitis, myocarditis, and acute flaccid paralysis. The detection and identification of echovirus genotypes in clinical samples is challenging due to its high genetic diversity. Here, we report the complete genome sequences of nine echoviruses, obtained by next-generation sequencing of 238 fecal samples from individuals with gastroenteritis in regions of Brazil. Detected viruses were classified into six genotypes: Three E1 sequences (BRA/TO-028, BRA/TO-069 and BRA/TO-236), one E3 (BRA/TO-018), one E11 (BRA/TO-086), one E20 (BRA/TO-016), two E29 (BRA/TO-030 and BRA/TO-193), and one E30 sequence (BRA/TO-032). Phylogenetic analysis indicated that the echoviruses E1 and E29 circulating in Brazil are divergent from strains circulating worldwide. The genotype diversity identified in our study may under-represent the total echovirus diversity in Brazil because of the small sample size and the restricted geographical distribution covered by the survey. (AU)

• Processo FAPESP: 19/21706-5 - Metagenômica viral de mosquitos capturados no Estado de São Paulo
• Beneficiário: Vanessa dos Santos Morais
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 17/00021-9 - Metagenômica viral da Dengue, Chikungunya e Zika: acompanhar, explicar e prever a transmissão e distribuição espaço-temporal no Brasil
• Beneficiário: Antonio Charlys da Costa
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 15/12944-9 - Investigando a evolução de cepas animais de rotavírus infectando humanos
• Beneficiário: Adriana Luchs
• Modalidade de apoio: Auxílio à Pesquisa - Regular