Expanding the Limits of Photodynamic Therapy: The Design of Organelles and Hypoxia-Targeting Nanomaterials for Enhanced Photokilling of Cancer

Autor(es)

Calori, Italo Rodrigo ^[1] ; Bi, Hong ^[2] ; Tedesco, Antonio Claudio ^{[2, 1]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo Ribeirao Preto, Fac Philosophy Sci & Letters Ribeirao Preto, Ctr Nanotechnol & Tissue Engn, Dept Chem, Photobiol & Photomed Res Grp, BR-14040901 Sao Paulo - Brazil

^[2] Anhui Univ, Sch Chem & Chem Engn, Anhui Key Lab Modern Biomfg, Hefei 230601 - Peoples R China

• Tipo de documento: Artigo de Revisão
• Fonte: ACS APPLIED BIO MATERIALS; v. 4, n. 1, p. 195-228, JAN 18 2021.
• Citações Web of Science: 5

Resumo

Photodynamic therapy (PDT) is a minimally invasive clinical protocol that combines a nontoxic photosensitizer (PS), appropriate visible light, and molecular oxygen for cancer treatment. This triad generates reactive oxygen species (ROS) in situ, leading to different cell death pathways and limiting the arrival of nutrients by irreversible destruction of the tumor vascular system. Despite the number of formulations and applications available, the advancement of therapy is hindered by some characteristics such as the hypoxic condition of solid tumors and the limited energy density (light fluence) that reaches the target. As a result, the use of PDT as a definitive monotherapy for cancer is generally restricted to pretumor lesions or neoplastic tissue of approximately 1 cm in size. To expand this limitation, researchers have synthesized functional nanoparticles (NPs) capable of carrying classical photosensitizers with self-supplying oxygen as well as targeting specific organelles such as mitochondria and lysosomes. This has improved outcomes in vitro and in vivo. This review highlights the basis of PDT, many of the most commonly used strategies of functionalization of smart NPs, and their potential to break the current limits of the classical protocol of PDT against cancer. The application and future perspectives of the multifunctional nanoparticles in PDT are also discussed in some detail. (AU)

• Processo FAPESP: 20/06523-9 - Utilização de nanocarreadores contendo fármacos fotossensibilizantes e outros ativos aplicados a terapia celular e tratamento de patologias do sistema nervoso central
• Beneficiário: Italo Rodrigo Calori
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 13/50181-1 - Utilização de nanocarreadores contendo fármacos fotossensibilizantes e outros ativos aplicados à terapia celular e tratamento de patologias do sistema nervoso central
• Beneficiário: Antonio Claudio Tedesco
• Modalidade de apoio: Auxílio à Pesquisa - Temático