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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Preventive oral supplementation with Bifidobacterium longum 5(1A) alleviates oxazolone-induced allergic contact dermatitis-like skin inflammation in mice

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Autor(es):
Ribeiro, W. R. [1] ; Queiroz, A. G. [1] ; Mendes, E. [1] ; Casaro, M. B. [1] ; Nascimento, C. M. [1] ; Coelho, L. S. S. F. [1] ; Martins, F. S. [2] ; Leite-Silva, V. R. [1, 3] ; Ferreira, C. M. [1]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Inst Environm Chem & Pharmaceut Sci, Dept Pharmaceut Sci, R Sao Nicolau 210, BR-09913030 Diadema, SP - Brazil
[2] Univ Fed Minas Gerais, Inst Biol Sci, Dept Microbiol, Ave Presidente Antonio Carlos 6627, BR-31970201 Ufmg Belo Horizonte, MG - Brazil
[3] Univ Queensland, Therapeut Res Ctr, Translat Res Inst, Diamantina Inst, 37 Kent St, Woolloongabba, Qld 4102 - Australia
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: BENEFICIAL MICROBES; v. 12, n. 2, p. 199-209, 2021.
Citações Web of Science: 1
Resumo

Allergic contact dermatitis (ACD) is a common allergic skin disease that affects individuals subjected to different antigen exposure conditions and significantly impacts the quality of life of those affected. Numerous studies have demonstrated that probiotics suppress inflammation through immunomodulatory effects. In this study, we aimed to evaluate the effect of the probiotic Bifidobacterium longum 5(1A) as a preventive treatment for ACD using an oxazolone-induced murine model. We demonstrated that B. longum 5(1A) exerted a prophylactic effect on oxazoloneinduced ACD-like skin inflammation via reductions in ear and dermal thickness and leucocyte infiltration. The administration of inactivated B. longum 5(1A) did not affect oxazolone-induced ACD-like skin inflammation, suggesting that the bacteria must be alive to be effective. Given that B. longum 5(1A) is an acetate producer, we treated mice with acetate intraperitoneally, which also prevented ear and dermal thickening. Moreover, the tissue levels of the inflammatory cytokines and chemokines interleukin (IL)-10, IL-33, tumour necrosis factor-alpha, chemokine (C-C motif) ligand 2/monocyte chemoattractant protein-1 and chemokine (C-C motif) ligand 5/RANTES were significantly reduced after probiotic treatment, but only IL-33 and IL-10 were reduced when the mice were treated with acetate. These results show that B. longum 5(1A) exerted a potential prophylactic effect on skin inflammation and that acetate represents one potential mechanism. However, other factors are likely involved since these two treatments do not yield the same results. (AU)

Processo FAPESP: 12/50410-8 - Efeito dos ácidos graxos de cadeia curta produzidos por bactérias probióticas na profilaxia e tratamento da inflamação alérgica das vias aéreas
Beneficiário:Caroline Marcantonio Ferreira
Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
Processo FAPESP: 19/12324-1 - Probiótico como uma ferramenta terapêutica no eixo pele-pulmão-intestino
Beneficiário:Caroline Marcantonio Ferreira
Modalidade de apoio: Auxílio à Pesquisa - Regular