Omega-3 Fatty Acids in Erythrocyte Membranes as Predictors of Lower Cardiovascular Risk in Adults without Previous Cardiovascular Events

Autor(es)

Ferreira Goncalinho, Gustavo Henrique ^[1] ; Sampaio, Geni Rodrigues ^[1] ; Manolio Soares-Freitas, Rosana Aparecida ^[1] ; Teixeira Damasceno, Nagila Raquel ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, BR-01246904 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NUTRIENTS; v. 13, n. 6 JUN 2021.
• Citações Web of Science: 0

Resumo

Background: This study investigated the association of omega-3 polyunsaturated fatty acids (n-3 PUFA) within erythrocyte membranes and cardiovascular risk assessed by three different estimates. Methods: Inclusion criteria were individuals of both sexes, 30 to 74 years, with at least one cardiovascular risk factor, and no previous cardiovascular events (n = 356). Exclusion criteria were individuals with acute or chronic severe diseases, infectious diseases, pregnant, and/or lactating women. Plasma biomarkers (lipids, glucose, and C-reactive protein) were analyzed, and nineteen erythrocyte membrane fatty acids (FA) were identified. The cardiovascular risk was estimated by Framingham (FRS), Reynolds (RRS), and ACC/AHA-2013 Risk Scores. Three patterns of FA were identified (Factor 1, poor in n-3 PUFA), (Factor 2, poor in PUFA), and (Factor 3, rich in n-3 PUFA). Results: Total cholesterol was inversely correlated with erythrocyte membranes C18:3 n-3 (r = -0.155; p = 0.004), C22:6 n-3 (r = -0.112; p = 0.041), and total n-3 (r = -0.211; p < 0.001). Total n-3 PUFA was associated with lower cardiovascular risk by FRS (OR = 0.811; 95% CI= 0.675-0.976). Regarding RRS, Factor 3 was associated with 25.3% lower odds to have moderate and high cardiovascular risk (OR = 0.747; 95% CI = 0.589-0.948). The ACC/AHA-2013 risk score was not associated with isolated and pooled FA. Conclusions: n-3 PUFA in erythrocyte membranes are independent predictors of low-risk classification estimated by FRS and RRS, which could be explained by cholesterol-lowering effects of n-3 PUFA. (AU)

• Processo FAPESP: 16/24531-3 - Propriedades estruturais e biofísicas de lipoproteínas nativa e modificada
• Beneficiário: Antonio Martins Figueiredo Neto
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 11/12523-2 - Propriedades físico-químicas da LDL e da HDL, marcadores cardiometabólicos e oxidativos podem ser modulados pelo consumo de ômega-3, ômega-6 e ômega-9 em indivíduos adultos?
• Beneficiário: Nágila Raquel Teixeira Damasceno
• Modalidade de apoio: Auxílio à Pesquisa - Regular