Cardioprotection stimulated by resveratrol and grape products prevents lethal cardiac arrhythmias in an animal model of ischemia and reperfusion

Autor(es)

Menezes-Rodrigues, Francisco Sandro ^[1] ; Errante, Paolo Ruggero ^[1] ; Araujo, Erisvaldo Amarante ^[1] ; Pacheco Fernandes, Mariana Pontes ^[2] ; da Silva, Michele Mendes ^[3] ; Pires-Oliveira, Marcelo ^[4] ; Scorza, Carla Alessandra ^[5] ; Scorza, Fulvio Alexandre ^[5] ; Taha, Murched Omar ^[6] ; Caricati-Neto, Afonso ^[7]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Lab Auton & Cardiovasc Pharmacol, Sao Paulo, SP - Brazil

^[2] Fac Oswaldo Cruz, Sao Paulo, SP - Brazil

^[3] Univ Paulista, Sao Paulo, SP - Brazil

^[4] Uniao Metropolitana Educ & Cultura, Sch Med, Lauro De Freitas, BA - Brazil

^[5] Univ Fed Sao Paulo, Dept Neurol & Neurosurg, Sao Paulo, SP - Brazil

^[6] Univ Fed Sao Paulo, Dept Surg, Sao Paulo, SP - Brazil

^[7] Univ Fed Sao Paulo, Dept Pharmacol, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Acta Cirurgica Brasileira; v. 36, n. 3 2021.
• Citações Web of Science: 0

Resumo

ABSTRACT Purpose To evaluate the preventive cardioprotective effects of resveratrol and grape products, such as grape juice and red wine, in animal model of cardiac ischemia and reperfusion. Methods Male Wistar rats orally pretreated for 21-days with resveratrol and grape products were anesthetized and placed on mechanical ventilation to surgically induce cardiac ischemia and reperfusion by obstruction (ischemia) followed by liberation (reperfusion) of blood circulation in left descending coronary artery. These rats were submitted to the electrocardiogram (ECG) analysis to evaluate the effects of pretreatment with resveratrol and grape products on the incidence of ventricular arrhythmias (VA), atrioventricular block (AVB) and lethality (LET) resulting from cardiac ischemia and reperfusion. Results It was observed that the incidence of AVB was significantly lower in rats pretreated with resveratrol (25%), grape juice (37.5%) or red wine (12.5%) than in rats treated with saline solution (80%) or ethanol (80%). Similarly, incidence of LET was also significantly lower in rats pretreated with resveratrol (25%), grape juice (25%) or red wine (0%) than in rats treated with saline solution (62.5%) or ethanol (75%). Conclusions These results indicate that the cardioprotective response stimulated by resveratrol and grape products prevents the lethal cardiac arrhythmias in animal model of ischemia and reperfusion, supporting the idea that this treatment can be beneficial for prevention of severe cardiac arrhythmias in patients with ischemic heart disease. (AU)

• Processo FAPESP: 17/25565-1 - Nova abordagem terapêutica da doença de Parkinson: Neuroproteção estimulada pela modulação farmacológica da sinalização intracelular pelo Ca2+/AMPc/NO
• Beneficiário: Afonso Caricati Neto
• Modalidade de apoio: Auxílio à Pesquisa - Regular