The protective roles of clusterin in ocular diseases caused by obesity and diabetes mellitus type 2

Autor(es):Mostrar menos -

de Campos, Thais Dantis Pereira ^[1] ; da Cruz Rodrigues, Kellen Cristina ^[1] ; Pereira, Rodrigo Martins ^[1] ; Anaruma, Chadi Pellegrini ^[1] ; dos Santos Canciglieri, Raphael ^[1] ; de Melo, Diego Gomes ^[1] ; da Silva, Adelino Sanchez Ramos ^[2] ; Cintra, Dennys Esper ^{[3, 4]} ; Ropelle, Eduardo Rochete ^{[3, 1]} ; Pauli, Jose Rodrigo ^{[3, 1]} ; de Moura, Leandro Pereira ^{[3, 1, 5]}

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Sch Appl Sci, Lab Mol Biol Exercise LaBMEx, 1300 Pedro Zaccaria St, Limeira, SP - Brazil

^[2] Univ Sao Paulo, Sch Phys Educ & Sport Ribeirao Preto, Ribeirao Preto, SP - Brazil

^[3] Univ Campinas UNICAMP, Sch Appl Sci, CEPECE Ctr Res Sport Sci, Limeira, SP - Brazil

^[4] Univ Estadual Campinas, Sch Appl Sci, Lab Nutrit Genom LABGeN, Limeira, SP - Brazil

^[5] Sao Paulo State Univ UNESP, Postgrad Program Motr Sci, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: MOLECULAR BIOLOGY REPORTS; v. 48, n. 5, p. 4637-4645, MAY 2021.
• Citações Web of Science: 0

Resumo

Obesity is a chronic, non-transmissible and multifactorial disease commonly associated with systemic inflammation and damage to health. This disorder has been pointed out as leading to the development of a diversity of eye diseases and, consequently, damage to visual acuity. More specifically, cardiometabolic risk is associated with lacrimal gland dysfunctions, since it changes the inflammatory profile favoring the development and worsening of dry eye disease. In more severe and extreme cases, obesity, inflammation, and diabetes mellitus type 2 can trigger the total loss of vision. In this scenario, besides its numerous metabolic functions, clusterin, an apolipoprotein, has been described as protective to the ocular surface through the seal mechanism. Thus, the current review aimed to explain the role of clusterin in dry eye disease that can be triggered by obesity and diabetes. (AU)

• Processo FAPESP: 18/06833-8 - Poderia o exercício físico melhorar a acuidade visual? efeitos de diferentes protocolos de treinamento físico na composição da lágrima e no metabolismo da clusterina / ApoJ na retina de roedores obesos
• Beneficiário: Thaís Dantis Pereira de Campos
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 15/07199-2 - Papel da clusterina/ApoJ na sinalização da insulina em resposta ao exercício físico em roedores e em humanos
• Beneficiário: Leandro Pereira de Moura
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores