Effects of fish oil supplementation on spatial memory in rats with pilocarpine-induced epilepsy assessed using the Morris Water Maze test

Autor(es)

Nejm, Mariana Bocca ^[1] ; Victorino, Daniella Balduino ^[1] ; Guimaraes-Marques, Marcia Jonathas ^[1] ; Scorza, Carla Alessandra ^[1] ; Finsterer, Josef ^[2] ; Scorza, Fulvio Alexandre ^[1] ; Cysneiros, Roberta Monterazzo ^[3]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Neurol & Neurocirurgia, Escola Paulista Med, Disciplina Neurociencia, Sao Paulo, SP - Brazil

^[2] Vet Univ Vienna, Messerli Inst, Krankenanstalt Rudolfstiftung, Vienna - Austria

^[3] Univ Presbiteriana Mackenzie, Lab Neurobiol & Metabolismo, Programa Posgrad Disturbios Desenvolvimento, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: EPILEPTIC DISORDERS; v. 23, n. 3, p. 476-484, JUN 2021.
• Citações Web of Science: 0

Resumo

Objective. Patients with temporal lobe epilepsy (TLE) are at high risk of experiencing cognitive impairment. Such dysfunction is also observed in an animal model of TLE, the rat model of pilocarpine-induced epilepsy. Methods. We investigated the effects of fish oil supplementation on spatial memory in rats with pilocarpine-induced epilepsy using the Morris Water Maze (MWM) test. Results. Although rats with pilocarpine-induced epilepsy treated with fish oil learned the platform location significantly faster by Day 7 of the acquisition phase, spatial memory performance of these rats was unaffected by fish oil supplementation during probe trials. Significance. Our study provides insights into the importance of considering nutraceutical strategies for enhancing cognitive abilities in patients with TLE. (AU)

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