Neutrophil Recruitment and Participation in Severe Diseases Caused by Flavivirus Infection

Autor(es)

Fontoura, Marina Alves ^{[1, 2]} ; Rocha, Rebeca Froes ^{[1, 3, 4]} ; Marques, Rafael Elias ^[1]

Afiliação do(s) autor(es)

^[1] Brazilian Ctr Res Energy & Mat CNPEM, Brazilian Biosci Natl Lab LNBio, BR-13083100 Campinas - Brazil

^[2] Univ Estadual Campinas, Inst Biol, Cellular & Struct Biol Grad Program, UNICAMP, BR-13083865 Campinas - Brazil

^[3] Univ Estadual Campinas, Inst Biol, Genet & Mol Biol Grad Program, UNICAMP, BR-13083970 Campinas - Brazil

^[4] Scripps Res Inst, Dept Integrat Struct & Computat Biol, La Jolla, CA 92037 - USA

• Tipo de documento: Artigo de Revisão
• Fonte: LIFE-BASEL; v. 11, n. 7 JUL 2021.
• Citações Web of Science: 0

Resumo

Neutrophils are first-line responders to infections and are recruited to target tissues through the action of chemoattractant molecules, such as chemokines. Neutrophils are crucial for the control of bacterial and fungal infections, but their role in the context of viral infections has been understudied. Flaviviruses are important human viral pathogens transmitted by arthropods. Infection with a flavivirus may result in a variety of complex disease manifestations, including hemorrhagic fever, encephalitis or congenital malformations. Our understanding of flaviviral diseases is incomplete, and so is the role of neutrophils in such diseases. Here we present a comprehensive overview on the participation of neutrophils in severe disease forms evolving from flavivirus infection, focusing on the role of chemokines and their receptors as main drivers of neutrophil function. Neutrophil activation during viral infection was shown to interfere in viral replication through effector functions, but the resulting inflammation is significant and may be detrimental to the host. For congenital infections in humans, neutrophil recruitment mediated by CXCL8 would be catastrophic. Evidence suggests that control of neutrophil recruitment to flavivirus-infected tissues may reduce immunopathology in experimental models and patients, with minimal loss to viral clearance. Further investigation on the roles of neutrophils in flaviviral infections may reveal unappreciated functions of this leukocyte population while increasing our understanding of flaviviral disease pathogenesis in its multiple forms. (AU)

• Processo FAPESP: 18/02594-9 - Estabelecimento de um modelo de infecção por usutu virus em camundongos: estudo da doença e teste de um composto neuroprotetor
• Beneficiário: Rebeca de Paiva Froes Rocha
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 18/10990-1 - Caracterização e potencial terapêutico de quimiocinas em sepse e encefalite induzida por Flavivirus
• Beneficiário: Rafael Elias Marques Pereira Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 19/20772-4 - Análise da resposta de anticorpos policlonais no contexto de infecção e imunização por Influenza A vírus
• Beneficiário: Rebeca de Paiva Froes Rocha
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado