Clinical Applications and Immunological Aspects of Electroporation-Based Therapies

Autor(es)

Luz, Jean Carlos dos Santos da ^[1] ; Antunes, Fernanda ^[1] ; Clavijo-Salomon, Maria Alejandra ^[2] ; Signori, Emanuela ^[3] ; Tessarollo, Nayara Gusmao ^[1] ; Strauss, Bryan E. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Canc Inst Sao Paulo, Viral Vector Lab, BR-01246000 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Canc Inst Sao Paulo, Lab Expt Oncol, BR-01246000 Sao Paulo - Brazil

^[3] CNR, Inst Translat Pharmacol, I-00133 Rome - Italy

• Tipo de documento: Artigo de Revisão
• Fonte: VACCINES; v. 9, n. 7 JUL 2021.
• Citações Web of Science: 1

Resumo

Reversible electropermeabilization (RE) is an ultrastructural phenomenon that transiently increases the permeability of the cell membrane upon application of electrical pulses. The technique was described in 1972 by Neumann and Rosenheck and is currently used in a variety of applications, from medicine to food processing. In oncology, RE is applied for the intracellular transport of chemotherapeutic drugs as well as the delivery of genetic material in gene therapies and vaccinations. This review summarizes the physical changes of the membrane, the particularities of bleomycin, and the immunological aspects involved in electrochemotherapy and gene electrotransfer, two important EP-based cancer therapies in human and veterinary oncology. (AU)

• Processo FAPESP: 17/25290-2 - O estudo do papel dos neoantígenos na modulação da resposta anti-tumoral promovido pelo tratamento com p19Arf e IFN-beta em células B16
• Beneficiário: Nayara Gusmão Tessarollo
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado