Glia and extracellular matrix molecules: What are their importance for the electrographic and MRI changes in the epileptogenic zone?

Autor(es)

Leite, Joao Pereira ^[1] ; Peixoto-Santos, Jose Eduardo ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Neurosci & Behav Sci, Ribeirao Preto - Brazil

^[2] Univ Fed Sao Paulo, Paulista Sch Med, Dept Neurol & Neurosurg, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Epilepsy & Behavior; v. 121, n. B AUG 2021.
• Citações Web of Science: 1

Resumo

Glial cells and extracellular matrix (ECM) molecules are crucial for the maintenance of brain homeostasis. Espe-cially because of their actions regarding neurotransmitter and ionic control, and synaptic function, these cells can potentially contribute to the hyperexcitability seen in the epileptogenic, while ECM changes are linked to synap-tic reorganization. The present review will explore glial and ECM homeostatic roles and their potential contribu-tion to tissue plasticity. Finally, we will address how glial, and ECM changes in the epileptogenic zone can be seen in magnetic resonance imaging (MRI), pointing out their importance as markers for the extension of the epilep-togenic area. This article is part of the Special Issue ``NEWroscience 2018{''}. (c) 2019 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 15/20840-9 - Correlatos histológicos de imagens por ressonância magnética em pacientes com epilepsias farmacorresistentes
• Beneficiário: José Eduardo Peixoto Santos
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 16/17882-4 - Epilepsias farmacorresistentes: desafios diagnósticos, estudo das comorbidades associadas e novas abordagens experimentais
• Beneficiário: João Pereira Leite
• Modalidade de apoio: Auxílio à Pesquisa - Temático