Glia and extracellular matrix molecules: What are their importance for the electrographic and MRI changes in the epileptogenic zone?

Author(s)

Leite, Joao Pereira ^[1] ; Peixoto-Santos, Jose Eduardo ^{[1, 2]}

Affiliation

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Neurosci & Behav Sci, Ribeirao Preto - Brazil

^[2] Univ Fed Sao Paulo, Paulista Sch Med, Dept Neurol & Neurosurg, Sao Paulo - Brazil

• Document type: Journal article
• Source: Epilepsy & Behavior; v. 121, n. B AUG 2021.
• Web of Science Citations: 1

Abstract

Glial cells and extracellular matrix (ECM) molecules are crucial for the maintenance of brain homeostasis. Espe-cially because of their actions regarding neurotransmitter and ionic control, and synaptic function, these cells can potentially contribute to the hyperexcitability seen in the epileptogenic, while ECM changes are linked to synap-tic reorganization. The present review will explore glial and ECM homeostatic roles and their potential contribu-tion to tissue plasticity. Finally, we will address how glial, and ECM changes in the epileptogenic zone can be seen in magnetic resonance imaging (MRI), pointing out their importance as markers for the extension of the epilep-togenic area. This article is part of the Special Issue ``NEWroscience 2018{''}. (c) 2019 Elsevier Inc. All rights reserved. (AU)

• FAPESP's process: 15/20840-9 - Histopathological correlates of magnetic resonance imaging in patients with drug-resistant epilepsies
• Grantee: José Eduardo Peixoto Santos
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 16/17882-4 - Drug-resistant epilepsies: diagnostic challenges, associated comorbidities and new experimental approaches
• Grantee: João Pereira Leite
• Support Opportunities: Research Projects - Thematic Grants