Amygdaloid complex anatomopathological findings in animal models of status epilepticus

Autor(es)

Tilelli, Cristiane Queixa ^[1] ; Flores, Larissa Ribeiro ^[1] ; Cota, Vinicius Rosa ^[2] ; de Castro, Olagide Wagner ^[3] ; Garcia-Cairasco, Norberto ^[4]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Joao del Rei, Lab Physiol, Campus Ctr Oeste Dona Lindu, BR-3550129 Divinopolis, MG - Brazil

^[2] Univ Fed Sao Joao Del Rei, Dept Elect Engn, Lab Neuroengn & Neurosci LINNce, Campus Santo Antonio, Praca Frei Orlando 170, BR-36307352 Sao Joao Del Rei, MG - Brazil

^[3] Univ Fed Alagoas, Inst Biol Sci & Hlth, Campus AC Simoes, Av Lourival Melo Mota S-N, BR-57072970 Maceio, AL - Brazil

^[4] Univ Sao Paulo, Sch Med, Dept Physiol, Neurophysiol & Expt Neuroethol Lab LNNE, Av Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Epilepsy & Behavior; v. 121, n. B AUG 2021.
• Citações Web of Science: 1

Resumo

Temporal lobe epileptic seizures are one of the most common and well-characterized types of epilepsies. The current knowledge on the pathology of temporal lobe epilepsy relies strongly on studies of epileptogenesis caused by experimentally induced status epilepticus (SE). Although several temporal lobe structures have been implicated in the epileptogenic process, the hippocampal formation is the temporal lobe structure studied in the greatest amount and detail. However, studies in human patients and animal models of temporal lobe epilepsy indicate that the amygdaloid complex can be also an important seizure generator, and several pathological processes have been shown in the amygdala during epileptogenesis. Therefore, in the present review, we systematically selected, organized, described, and analyzed the current knowledge on anatomopathological data associated with the amygdaloid complex during SE-induced epileptogenesis. Amygdaloid complex participation in the epileptogenic process is evidenced, among others, by alterations in energy metabolism, circulatory, and fluid regulation, neurotransmission, immediate early genes expression, tissue damage, cell suffering, inflammation, and neuroprotection. We conclude that major efforts should be made in order to include the amygdaloid complex as an important target area for evaluation in future research on SE-induced epileptogenesis. This article is part of the Special Issue \& ldquo;NEWroscience 2018 \& rdquo;. (c) 2019 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 14/50891-1 - INCT 2014: Translacional em Medicina
• Beneficiário: Jaime Eduardo Cecilio Hallak
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 19/05957-8 - Epilepsias e comorbidades neuropsiquiátricas: caracterização dos efeitos do tratamento com canabidiol e HUF-101 em modelos experimentais in vivo e in vitro
• Beneficiário: Norberto Garcia Cairasco
• Modalidade de apoio: Auxílio à Pesquisa - Regular