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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Antiglycation and antitumoral activity of Tribulus terrestris dry extract

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Autor(es):
Malaguti Figueiredo, Celia Cristina [1] ; Gomes, Amanda Costa [1] ; Granero, Filipe Oliveira [1] ; Bronzel Junior, Joao Luiz [1] ; Silva, Luciana Pereira [2] ; Tasca Gois Ruiz, Ana Lucia [3] ; Goncalves da Silva, Regildo Marcio [1, 4]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ UNESP, Inst Chem, Araraquara, SP - Brazil
[2] Fundacao Educ Municlpio Assis FEMA, Assis, SP - Brazil
[3] Univ Estadual Campinas, Fac Pharmaceut Sci, UNICAMP, Campinas, SP - Brazil
[4] Sao Paulo State Univ UNESP, Sch Sci Humanities & Languages, Dept Biotechnol, Lab Herbal Med & Nat Prod, Assis, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: AVICENNA JOURNAL OF PHYTOMEDICINE; v. 11, n. 3, p. 224-237, MAY-JUN 2021.
Citações Web of Science: 0
Resumo

Objective: Investigation of the antiglycation and antitumoral potential of standardized and saponins-enriched extracts of Tribulus terrestris herbal medicine. Materials and Methods: The procedures for the evaluation of the antiglycation activity of the standardized (TtSE) and saponins-enriched (TtEE) extracts of T. terrestris were: determination of relative mobility in electrophoresis (RME), free amino groups using OPA method and advanced glycation end-products (AGEs) fluorescence. Antioxidant activity was determined by DPPH radical scavenging test. In vitro antitumor activity of TtSE and TtEE was evaluated in human tumor cell lines. Results: The results were obtained by antiglycation tests (RME, OPA method and AGEs fluorescence determination), using BSA as protein and ribose as glycation agent, and antioxidant assay (DPPH test); it was verified that both extracts of T. terrestris have antiglycation and antioxidant activity. In addition, the extracts were able to induce death of more than 50% of human tumor cell lines. Conclusion: The present study showed that standardized and saponins-enriched extracts of T. terrestris herbal medicine present antiglycation and antioxidant and antiproliferative action in human tumor cells lines. The saponins-enriched extract proved a greater antiglycation and antioxidant activity in comparison to the standardized type. (AU)

Processo FAPESP: 15/17893-3 - Atividade antioxidante, antiglicante e microencapsulação de extrato e saponinas obtidas de Tribulus terrestris
Beneficiário:Célia Cristina Malaguti Figueiredo
Modalidade de apoio: Bolsas no Brasil - Mestrado