Modulatory effects of photobiomodulation in the anterior cingulate cortex of diabetic rats

Autor(es)

Correia Rocha, Igor Rafael ^[1] ; Chacur, Marucia ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Anat, Ave Lineu Prestes 2415, Room 007, BR-05508900 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES; v. 20, n. 6, p. 781-790, JUN 2021.
• Citações Web of Science: 0

Resumo

Anterior Cingulate Cortex (ACC) has a crucial contribution to higher order pain processing. Photobiomodulation (PBM) has being used as integrative medicine for pain treatment and for a variety of nervous system disorders. This study evaluated the effects of PBM in the ACC of diabetic rats. Type 1 diabetes was induced by a single dose of streptozotocin (85 mg/Kg). A total of ten sessions of PBM (pulsed gallium-arsenide laser, 904 nm, 9500 Hz, 6.23 J/cm(2)) was applied to the rat peripheral nervous system. Glial fibrillary acidic protein (GFAP), mu-opioid receptor (MOR), glutamate receptor 1 (GluR1), and glutamic acid decarboxylase (GAD65/67) protein level expression were analyzed in the ACC of diabetic rats treated with PBM. Our data revealed that PBM decreased 79.5% of GFAP protein levels in the ACC of STZ rats. Moreover, STZ + PBM rats had protein levels of MOR increased 14.7% in the ACC. Interestingly, STZ + PBM rats had a decrease in 70.7% of GluR1 protein level in the ACC. Additionally, PBM decreased 45.5% of GAD65/67 protein levels in the ACC of STZ rats. (AU)

• Processo FAPESP: 17/25554-0 - Estudo dos efeitos da fotobioestimulação sobre o metabolismo energético mitocondrial das células de Schwann no Diabetes Mellitus Tipo 1
• Beneficiário: Igor Rafael Correia Rocha
• Modalidade de apoio: Bolsas no Brasil - Doutorado