| Texto completo | |
| Autor(es): Mostrar menos - |
Braun, Glaucia H.
[1, 2]
;
Ramos, Henrique P.
[1]
;
Candido, Ana C. B. B.
[1]
;
Pedroso, Rita C. N.
[1]
;
Siqueira, Katia A.
[3]
;
Soares, Marcos A.
[3]
;
Dias, Gustavo M.
[4]
;
Magalhaes, Lizandra G.
[1]
;
Ambrosio, Sergio R.
[1]
;
Januario, Ana H.
[1]
;
Pietro, Rosemeire C. L. R.
[2]
Número total de Autores: 11
|
| Afiliação do(s) autor(es): | [1] Univ Franca, Nucleo Pesquisas Ciencias Exatas & Tecnol, Franca, SP - Brazil
[2] UNESP Univ Estadual Paulista, Fac Ciencias Farmaceut, Dept Farmacos & Medicamentos, Araraquara, SP - Brazil
[3] Univ Fed Mato Grosso, Inst Biociencias, Dept Bot & Ecol, Cuiaba, Mato Grosso - Brazil
[4] Univ Fed ABC, Ctr Ciencias Nat & Humanas, Sao Bernardo Do Campo, SP - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | NATURAL PRODUCT RESEARCH; v. 35, n. 10, p. 1644-1647, MAY 19 2021. |
| Citações Web of Science: | 7 |
| Resumo | |
Fractionation of extracts from the culture broth of the marine-derived fungus, Paecilomyces sp. 7A22, resulted in the isolation of the harzialactone A (HA), a known compound previously isolated from fungi of marine environments. The chemical structure of HA was determined by spectroscopic analyses. Upon evaluation of HA on antileishmanial assays against Leishmania amazonensis, HA exhibited significant activity against promastigotes forms with IC50 of 5.25 mu g mL(-1) and moderate activity against intracellular amastigotes with IC50 of 18.18 mu g mL(-1). This is the first report on the antileishmanial activity of HA, and the effects of HA presented in this work suggest that this class of compounds are suitable for future biological in vitro and in vivo studies for the search of natural products with activity against Leishmania spp. Furthermore, the present results corroborate marine-derived fungi as a promising source of natural products with antiparasitic activity. (AU) | |
| Processo FAPESP: | 17/14261-1 - Investigação do potencial esquistossomicida, leishmanicida e citototóxico de linhagens fúngicas associadas a invertebrados marinhos pertencentes a Ascidiacea |
| Beneficiário: | Ana Helena Januário |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 14/19184-7 - Investigação do potencial esquistossomicida de invertebrados marinhos pertencentes à Ascidiacea |
| Beneficiário: | Ana Helena Januário |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |