Spongiotic hyperplasia of the oral mucosa: case series and immunohistochemical analysis

Autor(es)

Silveira, Heitor Albergoni ^{[1, 2]} ; Toral-Rizo, Victor Hugo ^[3] ; Lara-Carrillo, Edith ^[3] ; Dominguete, Matheus Henrique Lopes ^[4] ; Silva, Evanio Vilela ^{[1, 2]} ; Ribeiro-Silva, Alfredo ^[5] ; Bufalino, Andreia ^[1] ; Almeida, Luciana Yamamoto ^[6] ; Leon, Jorge Esquiche ^[2]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Araraquara Dent Sch, Dept Diag & Surg, Araraquara, SP - Brazil

^[2] Univ Sao Paulo, Ribeirao Preto Dent Sch FORP USP, Oral Pathol, Dept Stomatol Publ Oral Hlth & Forens Dent, BR-14040904 Ribeirao Preto, SP - Brazil

^[3] Natl Autonomous Mexico, Sch Dent, Toluca - Mexico

^[4] Univ Vale Rio Verde UninCor, Tres Coracoes, MG - Brazil

^[5] Univ Sao Paulo, Ribeirao Preto Med Sch FMRP USP, Dept Pathol & Forens Med, Ribeirao Preto, SP - Brazil

^[6] Univ Estadual Paulista UNESP, Dept Diag & Surg, Rua Humaita 1680, BR-14801903 Araraquara, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ORAL AND MAXILLOFACIAL SURGERY-HEIDELBERG; AUG 2021.
• Citações Web of Science: 0

Resumo

The localized juvenile spongiotic gingival hyperplasia (LJSGH) mainly affects the maxillary vestibular attached gingiva of juvenile patients, without sex predilection. Similar lesions involving extragingival sites have not been reported to date. Here, we report 2 cases of extragingival soft tissue lesions with similar clinicopathological features to those reported in LJSGH and 12 cases of intraoral reactive soft tissue lesions microscopically showing LJSGH-like focal areas. The 2 cases were adult patients, affecting the maxillary alveolar ridge (55-year-old female) and hard palate (78-year-old male), which were diagnosed as ``spongiotic hyperplasia of the oral mucosa.{''} The 12 intraoral reactive soft tissue lesions (6 men and 6 women; mean age, 49.5 years) were diagnosed as inflammatory fibrous hyperplasia (n = 6), peripheral ossifying fibroma (n = 3), and pyogenic granuloma (n = 3), each of them presenting LJSGH-like focal areas. By immunohistochemistry, the spongiotic hyperplasia areas showed positivity for CK19, CK14, CK34 beta E12, and CAM5.2 (weak/focal), while CK4 was negative. Considering the anatomical locations (extragingival) of these 2 cases, the term ``spongiotic hyperplasia of the oral mucosa{''} is suggested. Moreover, LJSGH-like focal areas can be detected when microscopically assessing common intraoral reactive soft tissue lesions. (AU)

• Processo FAPESP: 17/01438-0 - Análise do papel da resposta imune inata e adaptativa na leucoplasia oral e leucoplasia verrucosa proliferativa
• Beneficiário: Andreia Bufalino
• Modalidade de apoio: Auxílio à Pesquisa - Regular
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• Beneficiário: Jorge Esquiche León
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/02713-2 - Efeitos da terapia com erlotinib e gefitinib em associação ao ácido all-trans retinóico e trióxido de arsênico na leucemia promielocítica aguda: estudo in vitro, ex vivo e em modelo experimental murino.
• Beneficiário: Luciana Yamamoto de Almeida
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 18/12734-2 - Caracterização imunoistoquímica comparativa de subgrupos de células dendríticas e oncogênese viral no carcinoma espinocelular oral e orofaríngeo
• Beneficiário: Heitor Albergoni da Silveira
• Modalidade de apoio: Bolsas no Brasil - Mestrado