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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Spongiotic hyperplasia of the oral mucosa: case series and immunohistochemical analysis

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Silveira, Heitor Albergoni [1, 2] ; Toral-Rizo, Victor Hugo [3] ; Lara-Carrillo, Edith [3] ; Dominguete, Matheus Henrique Lopes [4] ; Silva, Evanio Vilela [1, 2] ; Ribeiro-Silva, Alfredo [5] ; Bufalino, Andreia [1] ; Almeida, Luciana Yamamoto [6] ; Leon, Jorge Esquiche [2]
Total Authors: 9
[1] Sao Paulo State Univ UNESP, Araraquara Dent Sch, Dept Diag & Surg, Araraquara, SP - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Dent Sch FORP USP, Oral Pathol, Dept Stomatol Publ Oral Hlth & Forens Dent, BR-14040904 Ribeirao Preto, SP - Brazil
[3] Natl Autonomous Mexico, Sch Dent, Toluca - Mexico
[4] Univ Vale Rio Verde UninCor, Tres Coracoes, MG - Brazil
[5] Univ Sao Paulo, Ribeirao Preto Med Sch FMRP USP, Dept Pathol & Forens Med, Ribeirao Preto, SP - Brazil
[6] Univ Estadual Paulista UNESP, Dept Diag & Surg, Rua Humaita 1680, BR-14801903 Araraquara, SP - Brazil
Total Affiliations: 6
Document type: Journal article
Web of Science Citations: 0

The localized juvenile spongiotic gingival hyperplasia (LJSGH) mainly affects the maxillary vestibular attached gingiva of juvenile patients, without sex predilection. Similar lesions involving extragingival sites have not been reported to date. Here, we report 2 cases of extragingival soft tissue lesions with similar clinicopathological features to those reported in LJSGH and 12 cases of intraoral reactive soft tissue lesions microscopically showing LJSGH-like focal areas. The 2 cases were adult patients, affecting the maxillary alveolar ridge (55-year-old female) and hard palate (78-year-old male), which were diagnosed as ``spongiotic hyperplasia of the oral mucosa.{''} The 12 intraoral reactive soft tissue lesions (6 men and 6 women; mean age, 49.5 years) were diagnosed as inflammatory fibrous hyperplasia (n = 6), peripheral ossifying fibroma (n = 3), and pyogenic granuloma (n = 3), each of them presenting LJSGH-like focal areas. By immunohistochemistry, the spongiotic hyperplasia areas showed positivity for CK19, CK14, CK34 beta E12, and CAM5.2 (weak/focal), while CK4 was negative. Considering the anatomical locations (extragingival) of these 2 cases, the term ``spongiotic hyperplasia of the oral mucosa{''} is suggested. Moreover, LJSGH-like focal areas can be detected when microscopically assessing common intraoral reactive soft tissue lesions. (AU)

FAPESP's process: 17/01438-0 - The role of the innate and adaptive immune responses in oral leukoplakia and oral proliferative verrucous leukoplakia
Grantee:Andreia Bufalino
Support type: Regular Research Grants
FAPESP's process: 16/11419-0 - Clinicopathological correlation of the degree of differentiation, tetraspanin expression, viral agents and cell proliferation in a large sample of squamous cell carcinoma of the head and neck region.
Grantee:Jorge Esquiche León
Support type: Regular Research Grants
FAPESP's process: 16/02713-2 - Effects of erlotinib and gefitinib therapy in combination with all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia: in vitro, ex vivo and murine experimental model studies.
Grantee:Luciana Yamamoto de Almeida
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 18/12734-2 - Comparative immunohistochemical characterization of dendritic cell subgroups and viral oncogenesis in oral and oropharyngeal squamous cell carcinoma
Grantee:Heitor Albergoni da Silveira
Support type: Scholarships in Brazil - Master