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Comparative immunohistochemical characterization of dendritic cell subgroups and viral oncogenesis in oral and oropharyngeal squamous cell carcinoma

Grant number: 18/12734-2
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): January 01, 2019
Effective date (End): February 29, 2020
Field of knowledge:Health Sciences - Dentistry - Dental Clinics
Principal Investigator:Jorge Esquiche León
Grantee:Heitor Albergoni da Silveira
Host Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

The head and neck squamous cell carcinoma (HNSCC) is the fifth most common type of cancer and the sixth cause of cancer death. Recent studies emphasize oral SCC (OSCC) as a distinct entity of oropharyngeal SCC (OPSCC), with the latter showing a better prognosis and closely associated with human papillomavirus (HPV) infection. The etiology of HNSCC is multifactorial; however, the OSCC is related to tobacco and alcohol abuse, while OPSCC is often associated with HPV infection. Dendritic cells (DCs) are important cells which regulate immune responses, including those linked to tumorigenesis, establishing a connection between the innate and adaptive immune system. They are divided into two groups: myeloid DCs (myDCs) and plasmocytoid DCs (pDCs), including immature DCs (imDCs) and mature DCs (mDCs) stages. The mDCs are responsible for initiate protective immune mechanisms against foreign agents, including virus, whereas imDCs induce immune tolerance. The objectives of the present study will be to comparatively analyze, for immunohistochemistry (IHC) and in situ hybridization (ISH), the myDCs and pDCs infiltration, including mDC and imDC subgroups, in the intratumoral compartment of OSCC (n=100) and OPSCC (n=50), as well as to analyze viral oncogenesis (HPV and Epstein-Barr virus [EBV]), focusing clinicopathological associations, prognostic and therapeutic factors. Our results aim to contribute to the elucidation of OSCC and OPSCC pathogenesis and to determine if differences in the DC subgroups infiltration, including their activation stages, in correlation with viral oncogenesis, may explain the biological behavior of these tumors. (AU)

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Scientific publications (21)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SILVEIRA, HEITOR ALBERGONI; ALMEIDA, LUCIANA YAMAMOTO; LOPES DOMINGUETE, MATHEUS HENRIQUE; PEREIRA GRACIANO, KAMILA PRADO; BUFALINO, ANDREIA; LEON, JORGE ESQUICHE. Intraoral epidermoid cyst with extensive elastofibromatous changes: an unusual finding. ORAL AND MAXILLOFACIAL SURGERY-HEIDELBERG, v. 23, n. 4, p. 493-497, . (18/12734-2, 16/11419-0)
SILVA, EVANIO VILELA; ALMEIDA, LUCIANA YAMAMOTO; BORTOLETTO, KAREN CRISTINE; QUERO, ISABELA BARBOSA; JACOMINI, FERNANDA CAROLINA; BENEVENUTO DE ANDRADE, BRUNO AUGUSTO; SILVEIRA, HEITOR ALBERGONI; DUARTE, ANDRESSA; PETEAN, FLAVIO CALIL; ROCHA, EDUARDO MELANI; et al. Focal lymphocytic sialadenitis and ectopic germinal centers in oral reactive lesions and primary Sjogren's syndrome: a comparative study. RHEUMATOLOGY INTERNATIONAL, . (16/02713-2, 16/14636-2, 18/12734-2, 16/11419-0)
SILVA, EVANIO V.; SILVEIRA, HEITOR A.; MESQUITA, ANA T. M.; ALMEIDA, LUCIANA Y.; RIBEIRO-SILVA, ALFREDO; LEON, JORGE E.. Elastofibromatous lesion as a differential diagnosis of white lesions of the oral mucosa. JOURNAL OF CUTANEOUS PATHOLOGY, v. 47, n. 3, p. 307+, . (18/12734-2, 16/11419-0, 16/02713-2)
LUCIANA YAMAMOTO ALMEIDA; HEITOR ALBERGONI SILVEIRA; EVÂNIO VILELA SILVA; CAMILA DE OLIVEIRA BARBEIRO; JOAQUIM AUGUSTO DE PAULA; ANDREIA BUFALINO; ALFREDO RIBEIRO-SILVA; JORGE ESQUICHE LEÓN. EBV-negative lymphoepithelial-like carcinoma of the lower lip. Autopsy and Case Reports, v. 10, n. 1, . (16/02713-2, 18/12734-2, 16/11419-0)
SILVEIRA, HEITOR ALBERGONI; SOUSA, LUCAS MOURA; SILVA, EVANIO VILELA; ALMEIDA, LANA KEI YAMAMOTO; SVERZUT, CASSIO EDVARD; TRIVELLATO, ALEXANDRE ELIAS; LEON, JORGE ESQUICHE. Primary intraosseous CD9-positive B-cell lymphoblastic lymphoma of the maxilla affecting a pediatric patient: Immunohistochemical and in situ hybridization analysis. Oral Oncology, v. 108, . (18/12734-2, 16/11419-0)
SILVA, EVANIO VILELA; SILVEIRA, HEITOR ALBERGONI; CANDIDO MOREIRA, THALES PERES; AUGUSTO, JEFFERSON; RAGUSA SILVA, PAULA VERONA; BUFALINO, ANDREIA; LEON, JORGE ESQUICHE. Non-Ulcerated and Ulcerated Necrotizing Sialometaplasia: Report of an Additional Case and Literature Review. INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY, v. 75, n. 3, p. 4-pg., . (18/12734-2, 16/11419-0, 17/01438-0, 22/12760-9)
SILVEIRA, HEITOR ALBERGONI; SILVA-SOUSA, YARA TERESINHA CORREA; REYES, MAGDALENA RAQUEL TORRES; BERNARDINI, VANESSA DA ROCHA; FLORIAM, LUIS JOSE; LEON, JORGE ESQUICHE. Pedunculated, papillary giant cell fibroma in a pediatric patient: An immunohistochemical and in situ hybridization study. PEDIATRIC DENTAL JOURNAL, v. 33, n. 1, p. 6-pg., . (16/11419-0, 18/12734-2, 22/12760-9)
SILVA, EVANIO, V; SILVEIRA, HEITOR A.; NOGUEIRA, GUSTAVO M.; CAMPOS, ANA C.; DA SILVA, ANDERSON T. F.; LEON, JORGE E.. Melanoacanthoma, Plasma Cell Cheilitis and Langerhans Cell Hyperplasia on the Lower Lip: An Unusual Association and Immunohistochemical Analysis. INDIAN JOURNAL OF DERMATOLOGY, v. 67, n. 4, p. 5-pg., . (16/11419-0, 18/12734-2)
SILVEIRA, HEITOR ALBERGONI; TORAL-RIZO, VICTOR HUGO; LARA-CARRILLO, EDITH; DOMINGUETE, MATHEUS HENRIQUE LOPES; SILVA, EVANIO VILELA; RIBEIRO-SILVA, ALFREDO; BUFALINO, ANDREIA; ALMEIDA, LUCIANA YAMAMOTO; LEON, JORGE ESQUICHE. Spongiotic hyperplasia of the oral mucosa: case series and immunohistochemical analysis. ORAL AND MAXILLOFACIAL SURGERY-HEIDELBERG, . (17/01438-0, 16/11419-0, 16/02713-2, 18/12734-2)
NEVES-SILVA, RODRIGO; ALMEIDA, LUCIANA Y.; SILVEIRA, HEITOR A.; COLTURATO, CARLA B. N.; DUARTE, ANDRESSA; FERRISSE, TULIO M.; SILVA, EVANIO, V; VANZOLIN, BARBARA F.; BUFALINO, ANDREIA; RIBEIRO-SILVA, ALFREDO; et al. SMARCB1 (INI-1) and NUT immunoexpression in a large series of head and neck carcinomas in a Brazilian reference center. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, v. 42, n. 3, p. 11-pg., . (16/02713-2, 16/11419-0, 18/12734-2)
NEVES-SILVA, RODRIGO; ALMEIDA, LUCIANA Y.; SILVEIRA, HEITOR A.; COLTURATO, CARLA B. N.; DUARTE, ANDRESSA; FERRISSE, TULIO M.; SILVA, V, EVANIO; VANZOLIN, BARBARA F.; BUFALINO, ANDREIA; RIBEIRO-SILVA, ALFREDO; et al. SMARCB1 (INI-1) and NUT immunoexpression in a large series of head and neck carcinomas in a Brazilian reference center. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, . (18/12734-2, 16/11419-0, 16/02713-2)
FERRISSE, TULIO M.; ALMEIDA, LUCIANA Y.; SILVEIRA, HEITOR A.; DE OLIVEIRA, ANALU B.; BUFALINO, ANDREIA; LEON, JORGE E.. Benign atypical intralymphatic CD30+lymphoid proliferation with activated regulatory T-cell phenotype in the oral cavity. JOURNAL OF CUTANEOUS PATHOLOGY, v. 46, n. 11, . (18/12734-2, 16/11419-0, 16/02713-2)
SILVEIRA, HEITOR ALBERGONI; ALMEID, LUCIANA YAMAMOTO; CARLOS, ROMAN; SILVAA, EVANIO VILELA; FERRISSE, TULIO MORANDIN; DUARTE, ANDRESSA; CARDOSO, SUZIENE CAROLINE SIVAILVA; POLANCO, XIOMARA BEATRIZ JIMENEZ; BUFALINO, ANDREIA; RIBEIRO-SILVA, ALFREDO; et al. Human papillomavirus co-infection and survival in oral and oropharyngeal squamous cell carcinoma: A study in 235 Brazilian patients. AURIS NASUS LARYNX, v. 49, n. 2, p. 13-pg., . (16/02713-2, 16/11419-0, 18/12734-2)
RODRIGO N. SILVA; HEITOR A. SILVEIRA; LUCIANA Y. ALMEIDA; CARLA N. B. COLTURATO; ALEXANDRE ELIAS TRIVELLATO; CASSIO E. SVERZUT; JORGE E. LEÓN. Carcinoma cuniculado gengival mimetizando um processo inflamatório/reativo. Jornal Brasileiro de Patologia e Medicina Laboratorial, v. 55, n. 5, p. 498-505, . (16/02713-2, 18/12734-2, 16/11419-0)
TEIXEIRA, LUCAS R.; ALMEIDA, LUCIANA Y.; SILVA, RODRIGO N.; MESQUITA, ANA T. M.; COLTURATO, CARLA B. N.; SILVEIRA, HEITOR A.; DUARTE, ANDRESSA; RIBEIRO-SILVA, ALFREDO; LEON, JORGE E.. Young and elderly oral squamous cell carcinoma patients present similar angiogenic profile and predominance of M2 macrophages: Comparative immunohistochemical study. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, v. 41, n. 12, p. 4111-4120, . (18/12734-2, 16/11419-0, 17/02502-4, 16/02713-2)
CAMILA DE OLIVEIRA BARBEIRO; ROBERTO HENRIQUE BARBEIRO; HEITOR ALBERGONI DA SILVEIRA; LUCIANA YAMAMOTO DE ALMEIDA; JORGE ESQUICHE LEÓN; ANDREIA BUFALINO. Maxillary dentigerous cyst showing squamous odontogenic tumor-like proliferation: surgical approach and literature review. Autopsy and Case Reports, v. 11, . (17/01438-0, 18/12734-2, 18/04954-2, 16/11419-0)
SILVEIRA, HEITOR ALBERGONI; COELHO, MARIA CAROLINA; SILVA, EVANIO VILELA; NOGUEIRA, GUSTAVO MILHOMENS; DIAZ, KATYA PULIDO; OLIVEIRA-SANTOS, CHRISTIANO; LEON, JORGE ESQUICHE. Maxillary Parosteal Osteosarcoma: Additional case Report and Literature Review of Surface Osteosarcomas. INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY, v. N/A, p. 5-pg., . (18/12734-2, 16/11419-0, 22/12760-9)
TRAVASSOS, DAPHINE CAXIAS; SILVEIRA, HEITOR ALBERGONI; SILVA, EVANIO VILELA; PANUCCI, BEATRIZ ZAMBONI MARTINS; DA SILVA FILHO, NILSON COELHO; SILVA, PAULA VERONA RAGUSA; BUFALINO, ANDREIA; LEON, JORGE ESQUICHE. Primary cutaneous CD8+cytotoxic T-cell lymphoma of the face with intraoral involvement, resulting in facial nerve palsy after chemotherapy. JOURNAL OF CUTANEOUS PATHOLOGY, v. 49, n. 6, p. 5-pg., . (16/11419-0, 18/12734-2)
ROCHA, AUDREY F. L.; MIOTTO, LARISSA N.; FERRISSE, TULIO M.; SILVEIRA, HEITOR A.; ALMEIDA, LUCIANA Y.; BUFALINO, ANDREIA; NAVARRO, CLAUDIA M.; LEON, JORGE E.. Low-fat and fat-free spindle cell lipomas in the oral cavity: Immunohistochemical analysis and review of the literature. JOURNAL OF CUTANEOUS PATHOLOGY, v. 46, n. 10, p. 778-783, . (18/12734-2, 16/11419-0)
SILVEIRA, HEITOR ALBERGONI; ALMEIDA, LUCIANA YAMAMOTO; WEEGE NONAKA, CASSIANO FRANCISCO; ALVES, POLLIANNA MUNIZ; RIBEIRO-SILVA, ALFREDO; LEON, JORGE ESQUICHE. Myoepithelial carcinoma with rhabdoid features in the maxillary sinus: Immunohistochemical and in situ hybridization analysis of a rare case. Oral Oncology, v. 93, p. 116-119, . (16/02713-2, 18/12734-2, 16/11419-0)
SILVEIRA, HEITOR ALBERGONI; RAGUSA SILVA, PAULA VERONA; PIMENTEL, BRUNA GONCALVES; NOGUEIRA, GUSTAVO MILHOMENS; CHAHUD, FERNANDO; BRUNALDI, MARIANGELA OTTOBONI; LEON, JORGE ESQUICHE. Lymphomatoid Papulosis "Type E" Affecting the Palate: A Detailed Case Report and Review of Literature. AMERICAN JOURNAL OF DERMATOPATHOLOGY, v. 45, n. 5, p. 4-pg., . (18/12734-2, 16/11419-0, 22/12760-9)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SILVEIRA, Heitor Albergoni da. Comparative immunohistochemistry characterization of subgroups of dendritic cells and viral oncogenesis in oral and oropharyngeal squamous cell carcinomas. 2020. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Odontologia. Araraquara Araraquara.

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