Neuropathology of the 21st century for the Latin American epilepsy community

Autor(es)

Peixoto-Santos, Jose Eduardo ^[1] ; Blumcke, Ingmar ^[2]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Paulista Sch Med, Dept Neurol & Neurosurg, Discipline Neurosci, Sao Paulo - Brazil

^[2] Univ Hosp Erlangen, Dept Neuropathol, Schwabachanlage 6 Kopfklin, D-91054 Erlangen - Germany

• Tipo de documento: Artigo de Revisão
• Fonte: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY; v. 90, n. SI, p. 51-59, AUG 2021.
• Citações Web of Science: 1

Resumo

Many people with epilepsy remain drug-resistant, despite continuous efforts and advances in research and treatment. It is mandatory to understand the epilepsy's underlying etiology, whether it is structural, genetic, infectious, metabolic, immune or (currently) unknown, as it contains major information about the clinical phenotype, cognitive comorbidities, (new) drug targets and also help to predict postsurgical outcome. A multimodal approach, including digital slides and multichannel immunofluorescence labelling can increase the diagnostic yield of subtle pathologies, while DNA methylation arrays could helps in the diagnosis of difficult-toclassify lesions. Such techniques are not always available, however, in low-income countries. Even without access to expensive molecular techniques, automated analysis scripts and machine learning algorithms can be developed by Latin American researchers to improve our diagnostic yield from routine Hematoxylin \& Eosin stained tissue sections. The pathology community of Latin America contributed substantially to our current knowledge of etiologies related to human epilepsies and experimental epilepsy models. To further boost the impact of Latin American research, local centers should adhere to modern, multimodal neuropathology techniques, integrate different levels of knowledge, and strengthen their scientific collaborations. Dedicated teaching courses in Epileptology, such as the Latin American Summer Schools of Epilepsy (LASSE) or International Summer School for Neuropathology and Epilepsy Surgery (INES) addressing young researcher and neurologists, are most successful to promote this endeavor. In this review, we will describe the state of neuropathology at the 21st century and also highlight Latin American researchers' contributions to the current knowledge in neuropathology of epilepsy. (AU)

• Processo FAPESP: 17/03739-8 - Correlatos histológicos de imagens por Ressonância Magnética em pacientes com epilepsias
• Beneficiário: José Eduardo Peixoto Santos
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado