Antifungal effects of Streptococcus mutans extract on Candida strains susceptible and resistant to fluconazole: An in vivo study

Autor(es)

Alves, Mariana de Sa ^[1] ; de Oliveira Fugisaki, Luciana Ruano ^[1] ; dos Santos, Jessica Diane ^[1] ; Scorzoni, Liliana ^[1] ; Medina, Rebeca Previate ^[2] ; Siqueira Silva, Dulce Helena ^[2] ; Junqueira, Juliana Campos ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Inst Sci & Technol, Dept Biosci & Oral Diag, Francisco Jose Longo 777, BR-12245000 Sao Jose Dos Campos, SP - Brazil

^[2] Sao Paulo State Univ UNESP, Inst Chem, Dept Organ Chem, BR-14800900 Araraquara, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Medical Mycology; v. 59, n. 7, p. 744-747, JUL 2021.
• Citações Web of Science: 0

Resumo

Previous studies showed that the crude extract obtained from Streptococcus mutans inhibited the growth of Candida albicans reference strains. In this study, we evaluated whether the antifungal effects of S. mutans extract can be extended to clinical Candida isolates, including C. albicans and non-abicans strains with different susceptibilities to fluconazole. We verified that S. mutans extract increased the survival of Galleria mellonella larvae infected with C. albicans and C. glabrata and inhibited the fungal cells in hemolymph. These antifungal effects occurred for both fluconazole-susceptible and fluconazole-resistant strains. However, larvae infected by C. krusei were not affected by S. mutans extract. Lay Summary Streptococcus mutans crude extract shows antifungal effects on clinical Candida strains susceptible and resistant to fluconazole in Galleria mellonella model. (AU)

• Processo FAPESP: 16/03395-4 - Atividade antimicrobiana de metabólitos produzidos por Streptococcus mutans sobre Candida albicans em modelos de estudo in vivo
• Beneficiário: Jéssica Diane dos Santos
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 16/05226-5 - Avaliação da atividade antimicrobiana de metabólitos produzidos por Streptococcus mutans sobre Candida albicans: estudo in vitro
• Beneficiário: Mariana de Sá Alves
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica