Emerging evidence for the opposite role of circulating irisin levels and brown adipose tissue activity measured by infrared thermography in anthropometric and metabolic profile during childhood

Autor(es)

De Meneck, Franciele ^[1] ; de Souza, Livia Victorino ^[1] ; Brioschi, Marcos Leal ^[2] ; Franco, Maria do Carmo ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Sch Med, Div Nephrol, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Med, Div Neurol Surg, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Thermal Biology; v. 99, JUL 2021.
• Citações Web of Science: 0

Resumo

Irisin is an adipomyokine that increases browning of adipose tissue and thermogenesis, thereby protecting against obesity and insulin resistance. However, the correlation between irisin, brown adipose tissue (BAT), and childhood obesity, as well as its association with an increased risk of developing metabolic diseases, has not been completely elucidated. This study aimed to investigate the association between irisin levels and BAT activity measured by infrared thermography among children and verify their correlation with anthropometric and metabolic parameters. This study included 42 children with normal weight and 18 overweight/obese children. Anthropometric data, irisin levels, lipid and glucose profile were evaluated. The percentage of the thermally active portion of the supraclavicular area (%AreaSCR) before and after a cold stimulus was measured by infrared thermography, and the differences between the percentages of thermally active (Delta%AreaSCR) was calculated as an index of BAT activation. The results were correlated with anthropometric and metabolic parameters. Circulating irisin levels was positive correlated with age (rho=0.327, P=0.011), body mass index (BMI) (rho=0.707, P<0.001), waist circumference (rho=0.624, P<0.001), total cholesterol (rho=0.361, P=0.044), triglycerides (rho=0.419, P=0.001), and low-density lipoprotein cholesterol (LDLc) (rho=0.381, P=0.003). Active BAT was negatively correlated with BMI, waist circumference, triglycerides, LDLc and irisin levels. We observed that normal weight children increased significantly the Delta% Area(SCR) as compared to overweight/obese children. In conclusion, circulating irisin levels and BAT activity appear to have opposing roles, since normal weight children had greater BAT activity and lower circulating levels of irisin. (AU)

• Processo FAPESP: 18/04013-3 - Quantificação da população de micropartículas de origem endotelial circulantes e análise do seu perfil de miRNAs: avaliação do impacto sobre a inter-relação entre o peso ao nascer, níveis pressóricos e função endotelial em crianças de 6 a 12 anos
• Beneficiário: Maria Do Carmo Pinho Franco
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/08361-3 - Avaliação das interações do exercício físico recreativo, peso ao nascer, níveis pressóricos e os componentes do sistema renina-angiotensina-calicreína-cininas em crianças
• Beneficiário: Livia Victorino de Souza
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado