Transcriptomic landscape of male and female reproductive cancers: Similar pathways and molecular signatures predicting response to endocrine therapy

Autor(es)

Camargo, Ana C. L. ^[1] ; Remoli, Beatriz ^[1] ; Portela, Luiz M. F. ^[1] ; Fioretto, Mateus N. ^[1] ; Chuffa, Luiz G. A. ^[1] ; Moreno, Carlos S. ^{[2, 3]} ; Justulin, Luis A. ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ, UNESP, Dept Struct & Funct Biol, Inst Biosci, BR-18618689 Botucatu, SP - Brazil

^[2] Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 - USA

^[3] Emory Univ, Dept Biomed Informat, Sch Med, Atlanta, GA - USA

• Tipo de documento: Artigo Científico
• Fonte: Molecular and Cellular Endocrinology; v. 535, SEP 15 2021.
• Citações Web of Science: 0

Resumo

Reproductive cancers in both genders represent serious health problems, whose incidence has significantly risen over the past decades. Although considerable differences among reproductive cancers exist, we aimed to identify similar signaling pathways and key molecular oncomarkers shared among six human reproductive cancers that can advance the current knowledge of cancer biology to propose new strategies for more effective therapies. Using a computational analysis approach, here we uncover aberrant miRNAs-mRNAs networks shared in six reproductive tumor types, and identify common molecular mechanisms strictly associated with cancer promotion and aggressiveness. Based on the fact that estrogenic and androgenic signaling pathways were most active in prostate and breast cancers, we further demonstrated that both androgen and estrogen deprivation therapy are capable of regulating the expression of the same key molecular sensors associated with endoplasmic reticulum dysfunction and cell cycle in these cancers. Overall, our data reveal a potential mechanistic framework of cellular processes that are shared among reproductive cancers, and particularly, highlight the importance of hormonal deprivation in breast and prostate cancers and potentially new biomarkers of response to these therapeutic approaches. (AU)

• Processo FAPESP: 18/09408-6 - Análise de RNA-seq para identificar alvos moleculares envolvidos na desregulação da morfogênese prostática em filhotes de ratos submetidos a restrição proteica materna.
• Beneficiário: Ana Carolina Lima Camargo
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 17/01063-7 - Análises globais integrativas da próstata ventral de ratos submetidos a restrição protéica materna e suas repercussões com o envelhecimento
• Beneficiário: Luis Antonio Justulin Junior
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/08715-0 - Análise integrativa do transcriptoma e proteômica da próstata ventral da prole de ratos submetidos à restrição protéica materna
• Beneficiário: Ana Carolina Lima Camargo
• Modalidade de apoio: Bolsas no Brasil - Doutorado