| Texto completo | |
| Autor(es): |
Guerra, Joao V. S.
[1, 2]
;
Dias, Marieli M. G.
[1, 3]
;
Brilhante, Anna J. V. C.
[3, 4]
;
Terra, Maiara F.
[1, 3]
;
Garcia-Arevalo, Marta
[1]
;
Figueira, Ana Carolina M.
[1]
Número total de Autores: 6
|
| Afiliação do(s) autor(es): | [1] Brazilian Ctr Res Energy & Mat CNPEM, Brazilian Biosci Natl Lab LNBio, Polo 2 Alta Tecnol R Giuseppe Maximo Scolfaro, BR-13083100 Campinas - Brazil
[2] Univ Estadual Campinas, Fac Pharmaceut Sci, Grad Program Pharmaceut Sci, BR-13083970 Campinas - Brazil
[3] State Univ Campinas Unicamp, Inst Biol, Grad Program Funct & Mol Biol, BR-13083970 Campinas - Brazil
[4] Brazilian Ctr Res Energy & Mat CNPEM, Brazilian Biorenewables Natl Lab LNBR, Polo 2 Alta Tecnol R Giuseppe Maximo Scolfaro, BR-13083100 Campinas - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo de Revisão |
| Fonte: | NUTRIENTS; v. 13, n. 8 AUG 2021. |
| Citações Web of Science: | 3 |
| Resumo | |
Throughout the 20th and 21st centuries, the incidence of non-communicable diseases (NCDs), also known as chronic diseases, has been increasing worldwide. Changes in dietary and physical activity patterns, along with genetic conditions, are the main factors that modulate the metabolism of individuals, leading to the development of NCDs. Obesity, diabetes, metabolic associated fatty liver disease (MAFLD), and cardiovascular diseases (CVDs) are classified in this group of chronic diseases. Therefore, understanding the underlying molecular mechanisms of these diseases leads us to develop more accurate and effective treatments to reduce or mitigate their prevalence in the population. Given the global relevance of NCDs and ongoing research progress, this article reviews the current understanding about NCDs and their related risk factors, with a focus on obesity, diabetes, MAFLD, and CVDs, summarizing the knowledge about their pathophysiology and highlighting the currently available and emerging therapeutic strategies, especially pharmacological interventions. All of these diseases play an important role in the contamination by the SARS-CoV-2 virus, as well as in the progression and severity of the symptoms of the coronavirus disease 2019 (COVID-19). Therefore, we briefly explore the relationship between NCDs and COVID-19. (AU) | |
| Processo FAPESP: | 19/14465-1 - Dissecção dos mecanismos de modulação do PPAR gama como alvo para o combate ao diabetes e o desenvolvimento da obesidade |
| Beneficiário: | Ana Carolina Migliorini Figueira |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 19/10274-7 - Estudo das interações PPARg-correguladores e sua relação com os processos de adipogênese e resistência insulina |
| Beneficiário: | Marieli Mariano Gonçalves Dias |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |