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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

The Natterin Proteins Diversity: A Review on Phylogeny, Structure, and Immune Function

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Autor(es):
Lima, Carla [1] ; Disner, Geonildo Rodrigo [1] ; Falcao, Maria Alice Pimentel [1] ; Seni-Silva, Ana Carolina [2, 1] ; Maleski, Adolfo Luis Almeida [2, 1] ; Souza, Milena Marcolino [1] ; Reis Tonello, Mayara Cristina [1] ; Lopes-Ferreira, Monica [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Butantan Inst, Immunoregulat Unit, Lab Appl Toxinol CeTICs FAPESP, Vital Brasil Ave, 1500 Butantan, BR-05503900 Sao Paulo - Brazil
[2] Butantan Inst, Postgrad Program Toxinol, BR-05503900 Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo de Revisão
Fonte: TOXINS; v. 13, n. 8 AUG 2021.
Citações Web of Science: 0
Resumo

Since the first record of the five founder members of the group of Natterin proteins in the venom of the medically significant fish Thalassophryne nattereri, new sequences have been identified in other species. In this work, we performed a detailed screening using available genome databases across a wide range of species to identify sequence members of the Natterin group, sequence similarities, conserved domains, and evolutionary relationships. The high-throughput tools have enabled us to dramatically expand the number of members within this group of proteins, which has a remote origin (around 400 million years ago) and is spread across Eukarya organisms, even in plants and primitive Agnathans jawless fish. Overall, the survey resulted in 331 species presenting Natterin-like proteins, mainly fish, and 859 putative genes. Besides fish, the groups with more species included in our analysis were insects and birds. The number and variety of annotations increased the knowledge of the obtained sequences in detail, such as the conserved motif AGIP in the pore-forming loop involved in the transmembrane barrel insertion, allowing us to classify them as important constituents of the innate immune defense system as effector molecules activating immune cells by interacting with conserved intracellular signaling mechanisms in the hosts. (AU)

Processo FAPESP: 13/07467-1 - CeTICS - Centro de Toxinas, Imuno-Resposta e Sinalização Celular
Beneficiário:Hugo Aguirre Armelin
Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 19/27677-7 - Estudo da indução de microRNAs regulatórios por TNP dependente da ativação do receptor de hidrocarboneto arílico (AhR)
Beneficiário:Geonildo Rodrigo Disner
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 19/02333-3 - Validação da importância funcional das natterinas na resposta imune inata em zebrafish por CRISPR-Cas9, um método de loss-of-function
Beneficiário:Ana Carolina de Seni Silva
Modalidade de apoio: Bolsas no Brasil - Mestrado