Depletion study and estimation of the withdrawal period for albendazole in tambaqui (Colossoma macropomum) parasitised by acanthocephalan (Neoechinorhynchus buttnerae) treated with albendazole-containing feed

Autor(es)

Cordeiro, Rafaelle Pereira ^[1] ; de Campos Braga, Patricia Aparecida ^[1] ; Souza Rocha, Maria Juliete ^[2] ; Chagas, Edsandra Campos ^[2] ; Reyes Reyes, Felix Guillermo ^[1]

Afiliação do(s) autor(es)

^[1] Univ Campinas UNICAMP, Sch Food Engn, Dept Food Sci, Rua Monteiro Lobato 80, BR-13083862 Campinas, SP - Brazil

^[2] EMBRAPA Amazonia Ocidental, Manaus, Amazonas - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure; v. 38, n. 11 SEP 2021.
• Citações Web of Science: 1

Resumo

This study provides the first data related to albendazole (ABZ) and its main metabolites {[}albendazole sulphoxide (ABZSO), albendazole sulphone (ABZSO(2)), and albendazole-2-amino sulphone (ABZ-2-NH2-SO2)] residue depletion in tambaqui (Colossoma macropomum) parasitised by acanthocephalan (Neoechinorhynchus buttnerae). The ABZ withdrawal period was also calculated. The fish received a daily dose of 10 mg ABZ kg(-1) body weight (b.w.) via medicated feed for 34 days. Samples of target tissue (muscle plus skin in natural proportions) were collected 24, 48, 72, 120, 168, 240, and 336 h after the end of ABZ administration. The quantitation of ABZ residues and its metabolites in the target tissue was performed using a validated ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) analytical method. After treatment, ABZ in the target tissue was rapidly metabolised over time, and ABZSO was the most persistent metabolite and was shown to be at the highest levels in the target tissue. Considering the maximum residue limit (MRL) established by Codex Alimentarius in the muscle (100 mu g kg(-1), species not specified), a withdrawal period of 4 days (112 degrees C-day) was estimated for the total residue (sum of ABZ and its metabolite residues). Considering data reported in the literature and data obtained in this study, it is suggested that the total residue be considered as marker residue to be adopted for fish in the legislative framework. (AU)

• Processo FAPESP: 13/50452-5 - Veterinary drugs: development and validation of bioanalytical methods using LC-MS/MS and MALDI-TOF-MS and its applications in sanitary surveillance and the development of fish farming in Brazil
• Beneficiário: Felix Guillermo Reyes Reyes
• Modalidade de apoio: Auxílio à Pesquisa - Parceria para Inovação Tecnológica - PITE