Pulmonary function changes in older adults with and without metabolic syndrome

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Rodrigues Brandao-Rangel, Maysa Alves ^{[1, 2]} ; Moraes-Ferreira, Renilson ^{[1, 2]} ; Oliveira-Junior, Manoel Carneiro ^[1] ; Santos-Dias, Alana ^[1] ; Lacerda Bachi, Andre Luis ^{[1, 3]} ; Gabriela-Pereira, Giovana ^[1] ; Freitas, Simone de Oliveira ^[1] ; Araujo-Rosa, Amanda Cristina ^{[1, 2]} ; Franco Oliveira, Luis Vicente ^[4] ; Frison, Claudio Ricardo ^[1] ; do Prado, Wagner Luiz ^[5] ; Raju, Raghavan Pillai ^[6] ; Balagopal, P. Babu ^{[7, 8, 9]} ; Vieira, Rodolfo P. ^{[1, 10, 2]}

Afiliação do(s) autor(es)

^[1] Brazilian Inst Teaching & Res Pulm & Exercise Imm, Rua Pedro Ernesto 240, BR-12245520 Sao Jose Dos Campos, SP - Brazil

^[2] Fed Univ Sao Paulo UNIFESP, Postgrad Program Sci Human Movement & Rehabil, Ave Ana Costa 95, BR-11060001 Santos, SP - Brazil

^[3] Fed Univ Sao Paulo UNIFESP, Dept Otorhinolaryngol, Rua Pedro de Toledo 947, BR-04039032 Sao Paulo - Brazil

^[4] UniEvangelica, Postgrad Program Human Movement & Rehabil, Ave Univ Km 3, 5, BR-75083515 Anapolis, Go - Brazil

^[5] Calif State Univ San Bernardino, Kinesiol Dept, San Bernardino, CA 92407 - USA

^[6] Augusta Univ, Med Coll Georgia, Dept Pharmacol & Toxicol, Augusta, GA - USA

^[7] Nemours Childrens Hlth Syst, Jacksonville, FL - USA

^[8] Mayo Clin, Coll Med, Jacksonville, FL 32224 - USA

^[9] Mayo Clin, Coll Med, Rochester, MN - USA

^[10] Univ Brasil, Postgrad Program Bioengn, Rua Carolina Fonseca 235, BR-08230030 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 11, n. 1 AUG 30 2021.
• Citações Web of Science: 0

Resumo

The low-grade inflammation associated with metabolic syndrome (MS) triggers functional and structural alterations in several organs. Whereas lung function impairment is well reported for older adult population, the effect of MS on functional and immunological responses in the lungs remains unclear. In this cross-sectional study we determined whether MS alters pulmonary function, and immunological responses in older adults with MS. The study sample consisted of older adults with MS (68 +/- 3 years old; n = 77) and without MS (67 +/- 3 years old; n = 77). Impulse oscillometry was used to evaluate airway and tissue resistance, and reactance. Biomarkers of inflammation and fibrosis were assessed in the blood and in breath condensate. The total resistance of the respiratory system (R5Hz; p < 0.009), and the resistance of the proximal (R20Hz; p < 0.001) and distal (R5Hz-R20Hz; p < 0.004) airways were higher in MS individuals compared to those without MS. Pro-inflammatory (leptin, IL-1beta, IL-8, p < 0.001; TNF-alpha, p < 0.04) and anti-inflammatory cytokines (adiponectin, IL-1ra, IL-10, p < 0.001), anti-fibrotic (relaxin 1, relaxin 3, Klotho, p < 0.001) and pro-fibrotic (VEGF, p < 0.001) factors were increased in sera and in breath condensate individuals with MS. The results show that MS adversely affect lung mechanics, function, and immunological response in older adults. The data offer a metabolic basis for the inflammaging of the lungs and suggest the lungs as a potential therapeutic target for controlling the immune response and delaying the onset of impaired lung function in older adults with MS. (AU)

• Processo FAPESP: 12/15165-2 - Papel da sinalização purinérgica e da sinalização SOCS-JAK-STAT nos efeitos antiinflamatórios do treinamento aeróbio em modelos experimentais de asma e em indivíduos asmáticos
• Beneficiário: Rodolfo de Paula Vieira
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 19/05739-0 - Papel das cininas nos efeitos anti-inflamatórios do treinamento aeróbio em modelo experimental de Asma
• Beneficiário: Maysa Alves Rodrigues Brandão Rangel
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 19/11008-9 - O papel do treinamento físico nas respostas pró e anti-fibróticas pulmonares de indivíduos asmáticos
• Beneficiário: Renilson Moraes Ferreira
• Modalidade de apoio: Bolsas no Brasil - Mestrado