A novel automated simulator of pediatric systemic circulation: Design and applications

Autor(es)

Torres, Daniel S. ^[1] ; Mazzetto, Marcelo ^[2] ; Cestari, Idagene A. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Escola Politecn, Av Prof Luciano Gualberto 380, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Inst Coracao, Hosp Clin HCFMUSP, Fac Med, Av Dr Eneas Carvalho Aguiar 44, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Biomedical Signal Processing and Control; v. 70, SEP 2021.
• Citações Web of Science: 0

Resumo

The technology of ventricular assist devices has shown unprecedented evolution over the last decade. Despite of it, there is still a great need of developing pediatric specific devices, thus highlighting the demand for flexible simulators, capable of emulating mechanical circulatory assistance in the setting of pediatric heart failure. The aim of this work was to design and build an automated simulator of the pediatric circulation. The simulator comprises a hydraulic circulation mock loop and an electronic system with its computational algorithms and its graphical user interface. The simulator includes left ventricle assist devices capable of generating pulsatile or continuous-flow. To demonstrate the applicability of the automated system developed, normal and heart failure conditions of pediatric patients were simulated and the contribution of left ventricular assist devices in restoring normal hemodynamics were quantified. Restoration of aortic flow was obtained with the use of continuous or pulsatile devices in heart failure simulated conditions. The system is user friendly and intuitive, allowing fast and reproducible adjustments of parameters, such as vascular resistance and compliance, and left ventricle preload, providing environments suitable for in vitro evaluation of pediatric left ventricle assist devices. (AU)

• Processo FAPESP: 14/00695-1 - Desenvolvimento de um simulador para avaliação de dispositivos pediátricos de assistência ventricular
• Beneficiário: Daniel Seidenberger Torres
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 12/50283-6 - Suporte circulatório em pacientes pediátricos: dispositivo de assistência ventricular e oxigenação extracorpórea
• Beneficiário: Idágene Aparecida Cestari
• Modalidade de apoio: Auxílio à Pesquisa - Temático