New perspectives on natural flavonoids on COVID-19-induced lung injuries

Autor(es)

Santana, Fernanda Paula R. ^{[1, 2]} ; Thevenard, Fernanda ^[3] ; Gomes, Kaio S. ^[3] ; Taguchi, Laura ^[1] ; Camara, Niels Olsen S. ^[2] ; Stilhano, Roberta S. ^[4] ; Ureshino, Rodrigo P. ^[5] ; Prado, Carla Maximo ^[1] ; Lago, Joao Henrique Ghilardi ^[3]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Biosci, Santos, SP - Brazil

^[2] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Sao Paulo, SP - Brazil

^[3] Fed Univ ABC, Ctr Nat Sci & Humanities, Sao Paulo, SP - Brazil

^[4] Santa Casa Sao Paulo Sch Med Sci, Dept Physiol Sci, Sao Paulo, SP - Brazil

^[5] Univ Fed Sao Paulo, Dept Biol Sci, Diadema, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Phytotherapy Research; v. 35, n. 9, p. 4988-5006, SEP 2021.
• Citações Web of Science: 2

Resumo

The SARS-CoV-2 virus, responsible for COVID-19, spread rapidly worldwide and became a pandemic in 2020. In some patients, the virus remains in the respiratory tract, causing pneumonia, respiratory failure, acute respiratory distress syndrome (ARDS), and sepsis, leading to death. Natural flavonoids (aglycone and glycosides) possess broad biological activities encompassing antiinflammatory, antiviral, antitumoral, antiallergic, antiplatelet, and antioxidant effects. While many studies have focused on the effects of natural flavonoids in experimental models, reports based on clinical trials are still insufficient. In this review, we highlight the effects of flavonoids in controlling pulmonary diseases, particularly the acute respiratory distress syndrome, a consequence of COVID-19, and their potential use in coronavirus-related diseases. Furthermore, we also focus on establishing a relationship between biological potential and chemical aspects of related flavonoids and discuss several possible mechanisms of action, pointing out some possible effects on COVID-19. (AU)

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