Dynamic Crosstalk between Vascular Smooth Muscle Cells and the Aged Extracellular Matrix

Autor(es)

Ribeiro-Silva, Joao Carlos ^[1] ; Nolasco, Patricia ^[2] ; Krieger, Jose Eduardo ^[1] ; Miyakawa, Ayumi Aurea ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Inst Coracao InCor, Lab Genet & Cardiol Mol LIM 13, BR-05403000 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Inst Biociencias, Dept Genet & Evolucao, Lab Nacl Celulas Tronco Embrionarias LaNCE USP, BR-05508060 Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 22, n. 18 SEP 2021.
• Citações Web of Science: 0

Resumo

Vascular aging is accompanied by the fragmentation of elastic fibers and collagen deposition, leading to reduced distensibility and increased vascular stiffness. A rigid artery facilitates elastin to degradation by MMPs, exposing vascular cells to greater mechanical stress and triggering signaling mechanisms that only exacerbate aging, creating a self-sustaining inflammatory environment that also promotes vascular calcification. In this review, we highlight the role of crosstalk between smooth muscle cells and the vascular extracellular matrix (ECM) and how aging promotes smooth muscle cell phenotypes that ultimately lead to mechanical impairment of aging arteries. Understanding the underlying mechanisms and the role of associated changes in ECM during aging may contribute to new approaches to prevent or delay arterial aging and the onset of cardiovascular diseases. (AU)

• Processo FAPESP: 16/50439-7 - A systems approach to identify and validate novel therapeutic targets to improve cardiac repair and regeneration following myocardial infarction
• Beneficiário: José Eduardo Krieger
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/11139-5 - Participação do CRP3 no processo de aneurisma de aorta abdominal
• Beneficiário: Ayumi Aurea Miyakawa Yamaguchi
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/50889-7 - INCT 2014: em Medicina Assistida por Computação Científica (INCT-MACC)
• Beneficiário: José Eduardo Krieger
• Modalidade de apoio: Auxílio à Pesquisa - Temático