Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Dynamic Crosstalk between Vascular Smooth Muscle Cells and the Aged Extracellular Matrix

Full text
Author(s):
Ribeiro-Silva, Joao Carlos [1] ; Nolasco, Patricia [2] ; Krieger, Jose Eduardo [1] ; Miyakawa, Ayumi Aurea [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Inst Coracao InCor, Lab Genet & Cardiol Mol LIM 13, BR-05403000 Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Biociencias, Dept Genet & Evolucao, Lab Nacl Celulas Tronco Embrionarias LaNCE USP, BR-05508060 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Review article
Source: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 22, n. 18 SEP 2021.
Web of Science Citations: 0
Abstract

Vascular aging is accompanied by the fragmentation of elastic fibers and collagen deposition, leading to reduced distensibility and increased vascular stiffness. A rigid artery facilitates elastin to degradation by MMPs, exposing vascular cells to greater mechanical stress and triggering signaling mechanisms that only exacerbate aging, creating a self-sustaining inflammatory environment that also promotes vascular calcification. In this review, we highlight the role of crosstalk between smooth muscle cells and the vascular extracellular matrix (ECM) and how aging promotes smooth muscle cell phenotypes that ultimately lead to mechanical impairment of aging arteries. Understanding the underlying mechanisms and the role of associated changes in ECM during aging may contribute to new approaches to prevent or delay arterial aging and the onset of cardiovascular diseases. (AU)

FAPESP's process: 16/50439-7 - A systems approach to identify and validate novel therapeutic targets to improve cardiac repair and regeneration following myocardial infarction
Grantee:José Eduardo Krieger
Support Opportunities: Regular Research Grants
FAPESP's process: 15/11139-5 - CRP3 participation in aortic aneurysm process
Grantee:Ayumi Aurea Miyakawa Yamaguchi
Support Opportunities: Regular Research Grants
FAPESP's process: 14/50889-7 - National Institute of Science and Technology Medicine Assisted by Scientific Computing (INCT-MACC)
Grantee:José Eduardo Krieger
Support Opportunities: Research Projects - Thematic Grants