Advanced search
Start date
Betweenand

National Institute of Science and Technology Medicine Assisted by Scientific Computing (INCT-MACC)

Grant number: 14/50889-7
Support Opportunities:Research Projects - Thematic Grants
Duration: July 01, 2017 - June 30, 2025
Field of knowledge:Health Sciences - Medicine
Convênio/Acordo: CNPq - INCTs
Principal Investigator:José Eduardo Krieger
Grantee:José Eduardo Krieger
Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Pesquisadores principais:
Alexandre da Costa Pereira ; Gustavo Carlos Buscaglia ; Idágene Aparecida Cestari ; Marco Antonio Gutierrez ; Paulo Mazzoncini de Azevedo Marques ; Pedro Alves Lemos Neto ; Sergio Shiguemi Furuie
Associated scholarship(s):21/14902-2 - Adaptive hybrid approach for left ventricle segmentation in Cardiac Magnetic Resonance Imaging, BP.DR
21/08797-1 - Identification and characterization of long non-coding RNAs (lncRNAs) that modulate cardiac extracellular matrix, BP.DR
20/14906-5 - Implementation of flexible sensors for diagnosis with data processing using information visualization and artificial intelligence, BP.TT
+ associated scholarships 19/22116-7 - Automatic segmentation of the left ventricle in cardiac magnetic ressonance exams, BP.MS
19/21236-9 - Computational modeling and validation of a pediatric intra-aortic balloon pump, BP.PD
19/11502-3 - Characterization of a new candidate gene involved in the heart rate control and development of cardiovascular risk: KAPTIN (Kptn), BP.PD
18/19888-5 - Radiation dose reduction in computed radiography (CR) mammography through image processing, BP.PD - associated scholarships

Abstract

The main goal of this proposal is to transfer for the Health System innovative medical applications oriented to computer-aided diagnosis, treatment, surgical planning, training and medical supportive decisions. The National Institute of Science and Technology in Medicine Assisted by Scientific Computing (INCT-MACC) has since 2008 successfully integrated a knowledge network for modern communication and multimedia transmission techniques. These resulted in the development and management of high performance cloud computing environments scientific computing applied to medicine, especially in the modeling and simulation of computational human physiological systems, promoting the development of medical image processing, scientific visualization and virtual reality innovative medical applications. The present goals are to deploy and test the above-mentioned medical applications in addition to modeling and incorporating of genomic, proteomic and metabolomics data to improve diagnosis prediction of diseases before they have time to manifest and to anticipate real c1inical therapeutic outcomes in a tertiary hospital. These goals shall be met by developing 16 specific aims as part of five general objectives: 1) consolidate the research and technological development and focus efforts in the integration of new data and development of algorithms at the frontier of science in the Medicine Assisted by Scientific Computing (MACC); 2) develop human resources at all academic levels and enable professionals in the rational and efficient use of this new knowledge; 3) transfer to society the new knowledge and inherent benefits; 4) transfer to the public and the private sectors scientific technological innovations, contributing with its immediate use to benefit population welfare; and 5) consolidate the INCT-MACC and its associated network as an international player among the few leading organizations in the computational modeling in medicine and its applications in health-care. The combined innovative and integrated strategies, as demonstrated by the outcomes from the INCT-MACC in the last period and the ones proposed here, may allow advances consistent with major global effort to reengineer the world Heath Systems to make them more efficient and universal within sustainable economic conditions for the developing and developed countries. Moreover, it is paramount to approach universal problems considering specificities of the local environment and genetic characteristics of our population, which has important local social-economic implications. The development of these objectives shall also enhance human capacity building on computational biomedicine applications and research and technology transfer to the public and private sectors. Finally, it is important to emphasize that this proposal for the 2015-21 period focus on the associated medical centers of the INCT-MACC network since they demand and will test the new applications and will integrate genomic data into new medical algorithms. Thus, to reflect these new priorities, there will be a change in coordination and headquarter will be transferred to InCor-HCFMUSP (the largest Latin American and a world Center for Cardiovascular Medicine). The past six years' experience of the INCT MACC provided great opportunity to identify things that did not work despite a successful evaluation of the outcomes. Thus, novel strategies detailed in methods were incorporated and a new group of 31 associate laboratories, headquartered in 11 states, and 17 foreign collaborator laboratories distributed in 7 countries were assembled to support the proposed goals and challenges. (AU)

Articles published in Pesquisa FAPESP Magazine about the research grant:
Artificial intelligence to help the heart 
Inteligencia artificial aplicada al corazón 
Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (40)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BLANCO, PABLO J.; BULANT, CARLOS A.; ARES, GONZALO D.; LEMOS, PEDRO A.; FEIJOO, RAUL A.. A simple coronary blood flow model to study the collateral flow index. BIOMECHANICS AND MODELING IN MECHANOBIOLOGY, v. 20, n. 4, p. 1365-1382, . (14/50889-7)
TESTA, RAFAEL LUIZ; MACHADO-LIMA, ARIANE; NUNES, FATIMA L. S.. Facial expression synthesis based on similar faces. MULTIMEDIA TOOLS AND APPLICATIONS, v. 80, n. 30, . (14/50889-7)
MAGALHAES TENORIO, ARIANE PRISCILLA; FALEIROS, MATHEUS CALIL; FERREIRA JUNIOR, JOSE RANIERY; DALTO, VITOR FAEDA; ASSAD, RODRIGO LUPPINO; LOUZADA-JUNIOR, PAULO; YOSHIDA, HIROYUKI; NOGUEIRA-BARBOSA, MARCELLO HENRIQUE; DE AZEVEDO-MARQUES, PAULO MAZZONCINI. A study of MRI-based radiomics biomarkers for sacroiliitis and spondyloarthritis. INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY, v. 15, n. 10, . (16/17078-0, 14/50889-7)
DELMONDES, PEDRO H. M.; NUNES, FATIMA L. S.. A systematic review of multi-slice and multi-frame descriptors in cardiac MRI exams. COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE, v. 221, p. 15-pg., . (14/50889-7)
ARANHA, RENAN VINICIUS; CASAES, ANDRE BIONDI; NUNES, FATIMA L. S.; KEMCZINSKI, A; SANTOS, CQ; TREVISAN, DG; GASPARINI, I; ZAINA, L; PEREIRA, M; MOTA, M; et al. Influence of environmental conditions in the performance of open-source software for facial expression recognition. IHC 2020: PROCEEDINGS OF THE 19TH BRAZILIAN SYMPOSIUM ON HUMAN FACTORS IN COMPUTING SYSTEMS, v. N/A, p. 10-pg., . (14/50889-7)
MEACCI, LUCA; PRIMICERIO, MARIO. Pandemic fatigue impact on COVID-19 spread: A mathematical modelling answer to the Italian scenario. RESULTS IN PHYSICS, v. 31, . (14/50889-7)
RODRIGUES, WELLINGTON F.; MIGUEL, CAMILA B.; AGOSTINHO, FERDINANDO; DA SILVA, V, GABRIELA; LAZO-CHICA, JAVIER E.; SCAPIN, SANDRA M. NARESSI; NAPIMOGA, MARCELO H.; TRINDADE-DA-SILVA, CARLOS A.; KRIEGER, JOSE E.; PEREIRA, ALEXANDRE DA COSTA; et al. Metabolomic Evaluation of Chronic Periodontal Disease in Older Adults. Mediators of Inflammation, v. 2021, . (14/50889-7)
CURY, L. F. M.; TALOU, G. D. MASO; YOUNES-IBRAHIM, M.; BLANCO, P. J.. Parallel generation of extensive vascular networks with application to an archetypal human kidney model. ROYAL SOCIETY OPEN SCIENCE, v. 8, n. 12, . (14/50889-7)
DE ARAUJO, HERMON FARIA; NUNES, FATIMA L. S.; MACHADO-LIMA, ARIANE; ACM. The impact of different facial expression intensities on the performance of pre-trained emotion recognition models. 37TH ANNUAL ACM SYMPOSIUM ON APPLIED COMPUTING, v. N/A, p. 8-pg., . (20/01992-0, 14/50889-7)
MUELLER, LUCAS O.; WATANABE, SANSUKE M.; TORO, ELEUTERIO F.; FEIJOO, RAUL A.; BLANCO, PABLO J.. An anatomically detailed arterial-venous network model. Cerebral and coronary circulation. FRONTIERS IN PHYSIOLOGY, v. 14, p. 19-pg., . (18/14221-2, 14/50889-7)
PINHEIRO-DE-SOUSA, IGUARACY; FONSECA-ALANIZ, MIRIAM H.; TEIXEIRA, SAMANTHA K.; RODRIGUES, V, MARILIZA; KRIEGER, JOSE E.. ncovering emergent phenotypes in endothelial cells by clustering of surrogates of cardiovascular risk factor. SCIENTIFIC REPORTS, v. 12, n. 1, . (14/50889-7, 13/17368-0)
MUNOZ, JUAN J. A. M.; DARIOLLI, RAFAEL; DA SILVA, CAIO MATEUS; NERI, ELIDA A.; VALADAO, IURI C.; TURACA, LAURO THIAGO; LIMA, VANESSA M.; PERES DE CARVALHO, MARIANA LOMBARDI; VELHO, MARILIZA R.; SOBIE, ERIC A.; et al. Time-regulated transcripts with the potential to modulate human pluripotent stem cell-derived cardiomyocyte differentiation. STEM CELL RESEARCH & THERAPY, v. 13, n. 1, p. 27-pg., . (16/07541-5, 14/50889-7, 13/17368-0, 15/50216-5, 14/24577-8)
SALLABERRY, LUCAS H.; TORI, ROMERO; NUNES, FATIMA L. S.. Automatic Performance Assessment in Three-dimensional Interactive Haptic Medical Simulators: A Systematic Review. ACM COMPUTING SURVEYS, v. 55, n. 7, p. 35-pg., . (14/50889-7)
CRUZ, DAVI DE OLIVEIRA; CHECHETTI, CARLOS; BRUCKI, SONIA MARIA DOZZI; TAKADA, LEONEL TADAO; NUNES, FATIMA L. S.. A comprehensive systematic review on mobile applications to support dementia patients. PERVASIVE AND MOBILE COMPUTING, v. 90, p. 35-pg., . (14/50889-7)
CARVALHO, CARLOS ROBERTO RIBEIRO; LAMAS, CELINA ALMEIDA; CHATE, RODRIGO CARUSO; SALGE, JOAO MARCOS; SAWAMURA, MARCIO VALENTE YAMADA; DE ALBUQUERQUE, ANDRE L. P.; TOUFEN JR, CARLOS; LIMA, DANIEL MARIO; GARCIA, MICHELLE LOUVAES; SCUDELLER, PAULA GOBI; et al. Long-term respiratory follow-up of ICU hospitalized COVID-19 patients: Prospective cohort study. PLoS One, v. 18, n. 1, p. 16-pg., . (14/50889-7, 16/17078-0)
CARDONA CARDENAS, DIEGO ARMANDO; FURUIE, SERGIO SHIGUEMI; LHOTSKA, L; SUKUPOVA, L; LACKOVIC, I; IBBOTT, GS. Improving Priors for USTC via Transmission Tomography: A Simulation Study. WORLD CONGRESS ON MEDICAL PHYSICS AND BIOMEDICAL ENGINEERING 2018, VOL 1, v. 68, n. 1, p. 5-pg., . (14/50889-7)
BLANCO, PABLO J.; BULANT, CARLOS A.; BEZERRA, CRISTIANO G.; MASO TALOU, GONZALO D.; PINTON, FABIO A.; ZIEMER, PAULO G. P.; FEIJOO, RAUL A.; GARCIA-GARCIA, HECTOR M.; LEMOS, PEDRO A.. Coronary arterial geometry: A comprehensive comparison of two imaging modalities. INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING, v. 37, n. 5, . (14/50889-7)
FERREIRA-JUNIOR, JOSE RANIERY; KOENIGKAM-SANTOS, MARCEL; MAGALHAES TENORIO, ARIANE PRISCILLA; FALEIROS, MATHEUS CALIL; GARCIA CIPRIANO, FEDERICO ENRIQUE; FABRO, ALEXANDRE TODOROVIC; NAPPI, JANNE; YOSHIDA, HIROYUKI; DE AZEVEDO-MARQUES, PAULO MAZZONCINI. CT-based radiomics for prediction of histologic subtype and metastatic disease in primary malignant lung neoplasms. INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY, v. 15, n. 1, . (14/50889-7, 16/17078-0)
ALVAREZ, L. A. MANSILLA; BULANT, C. A.; ARES, G. D.; FEIJOO, R. A.; BLANCO, P. J.. A mid-fidelity numerical method for blood flow in deformable vessels. COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING, v. 392, p. 16-pg., . (14/50889-7)
VELLASCO, LUCAS; SVENSJO, ERIK; BULANT, CARLOS ALBERTO; BLANCO, PABLO JAVIER; NOGUEIRA, FABIO; DOMONT, GILBERTO; DE ALMEIDA, NATALIA PINTO; NASCIMENTO, CLARISSA RODRIGUES; SILVA-DOS-SANTOS, DANIELLE; CARVALHO-PINTO, CARLA EPONINA; et al. Sheltered in Stromal Tissue Cells, Trypanosoma cruzi Orchestrates Inflammatory Neovascularization via Activation of the Mast Cell Chymase Pathway. PATHOGENS, v. 11, n. 2, p. 29-pg., . (18/14221-2, 14/50889-7)
IBANEZ-REDIN, GISELA; CAGNANI, GIOVANA ROSSO; GOMES, NATHALIA O.; RAYMUNDO-PEREIRA, PAULO A.; MACHADO, SERGIO A. S.; GUTIERREZ, MARCO ANTONIO; KRIEGER, JOSE EDUARDO; OLIVEIRA, OSVALDO N.. Wearable potentiometric biosensor for analysis of urea in sweat. BIOSENSORS & BIOELECTRONICS, v. 223, p. 8-pg., . (14/50889-7, 18/22214-6, 22/02164-0, 20/09587-8, 16/01919-6, 20/14906-5)
RIBEIRO-SILVA, JOAO CARLOS; NOLASCO, PATRICIA; KRIEGER, JOSE EDUARDO; MIYAKAWA, AYUMI AUREA. Dynamic Crosstalk between Vascular Smooth Muscle Cells and the Aged Extracellular Matrix. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 22, n. 18, . (16/50439-7, 15/11139-5, 14/50889-7)
MEACCI, LUCA; PRIMICERIO, MARIO; BUSCAGLIA, GUSTAVO CARLOS. Growth of tumours with stem cells: The effect of crowding and ageing of cells. PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS, v. 570, . (18/08752-5, 14/50889-7)
BLANCO, PABLO J.; BULANT, CARLOS A.; ARES, GONZALO D.; LEMOS, PEDRO A.; FEIJOO, RAUL A.. A simple coronary blood flow model to study the collateral flow index. BIOMECHANICS AND MODELING IN MECHANOBIOLOGY, . (14/50889-7)
MANSILLA ALVAREZ, L. A.; BULANT, C. A.; ARES, G. D.; FEIJOO, R. A.; BLANCO, P. J.. easibility of coronary blood flow simulations using mid-fidelity numeric and geometric model. BIOMECHANICS AND MODELING IN MECHANOBIOLOGY, v. 21, n. 1, . (14/50889-7)
MAGALHAES TENORIO, ARIANE PRISCILLA; FERREIRA-JUNIOR, JOSE RANIERY; DALTO, VITOR FAEDA; FALEIROS, MATHEUS CALIL; ASSAD, RODRIGO LUPPINO; LOUZADA-JUNIOR, PAULO; NOGUEIRA-BARBOSA, MARCELLO HENRIQUE; RANGAYYAN, RANGARAJ MANDAYAM; DE AZEVEDO-MARQUES, PAULO MAZZONCINI. adiomic Quantification for MRI Assessment of Sacroiliac Joints of Patients with Spondyloarthriti. JOURNAL OF DIGITAL IMAGING, v. 35, n. 1, . (14/50889-7, 16/17078-0)
BLANCO, PABLO J.; VARGAS DOS SANTOS, GABRIELA H.; BULANT, CARLOS A.; ALVAREZ, ALONSO M.; OLIVEIRA, FREDRIC A. P.; CUNHA-LIMA, GABRIELLA; LEMOS, PEDRO A.. caling laws and the left main coronary artery bifurcation. A combination of geometric and simulation analyse. MEDICAL ENGINEERING & PHYSICS, v. 99, . (18/14221-2, 14/50889-7)
ARANHA, RENAN VINICIUS; CORDEIRO, LEONARDO NOGUEIRA; SALES, LUCAS MENDES; NUNES, FATIMA L. S.; ARDITO, C; LANZILOTTI, R; MALIZIA, A; PETRIE, H; PICCINNO, A; DESOLDA, G; et al. Engagement and Discrete Emotions in Game Scenario: Is There a Relation Among Them?. HUMAN-COMPUTER INTERACTION, INTERACT 2021, PT III, v. 12934, p. 21-pg., . (14/50889-7)
NOROOZBABAEE, LEYLA; BLANCO, PABLO J.; SAFAEI, SOROUSH; NICKERSON, DAVID P.. A modular and reusable model of epithelial transport in the proximal convoluted tubule. PLoS One, v. 17, n. 11, p. 30-pg., . (14/50889-7, 18/14221-2)
GHITTI, BEATRICE; BLANCO, PABLO J.; TORO, ELEUTERIO F.; MULLER, LUCAS O.. Construction of hybrid 1D-0D networks for efficient and accurate blood flow simulations. International Journal for Numerical Methods in Fluids, v. 95, n. 2, p. 51-pg., . (14/50889-7)
GIRAO-SILVA, THAIS; FONSECA-ALANIZ, MIRIAM HELENA; DALLAN, LUIS ALBERTO OLIVEIRA; VALADAO, IURI CORDEIRO; DA ROCHA, HENRIQUE OLIVEIRA; KRIEGER, JOSE EDUARDO; MIYAKAWA, AYUMI AUREA. Human Saphenous Vein Endothelial Cell Isolation and Exposure to Controlled Levels of Shear Stress and Stretch. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, v. N/A, n. 194, p. 14-pg., . (15/11139-5, 14/50889-7, 13/17368-0)
ALVAREZ, L. A. MANSILLA; ARES, G. D.; FEIJOO, R. A.; BLANCO, P. J.. A mixed-order interpolation solid element for efficient arterial wall simulations. COMPUTATIONAL MECHANICS, v. N/A, p. 21-pg., . (14/50889-7)
MEACCI, LUCA; PRIMICERIO, MARIO. Interaction between crowding and growth in tumours with stem cells: Conceptual mathematical modelling. MATHEMATICAL MODELLING OF NATURAL PHENOMENA, v. 18, p. 22-pg., . (14/50889-7)
FEIJOO, RAUL A.; BLANCO, PABLO J.; NETO, EDUARDO A. DE SOUZA A.; SANCHEZ, PABLO J.. Novel multiscale models in a multicontinuum approach to divide and conquer strategies. COMPUTATIONAL & APPLIED MATHEMATICS, v. 42, n. 4, p. 39-pg., . (18/14221-2, 14/50889-7)
MEACCI, LUCA; DI BARI, VINCENZO; AUSAS, ROBERTO FEDERICO; MUT, FERNANDO; GRAY, DAVID ALISTAIR; BUSCAGLIA, GUSTAVO CARLOS. A mathematical model of a single seed oleosome. RESULTS IN APPLIED MATHEMATICS, v. 9, p. 9-pg., . (14/50889-7)
OLIVEIRA, JESSICA S.; FRANCO, FELIPE O.; REVERS, MIRIAN C.; SILVA, ANDREIA F.; PORTOLESE, JOANA; BRENTANI, HELENA; MACHADO-LIMA, ARIANE; NUNES, FATIMA L. S.. Computer-aided autism diagnosis based on visual attention models using eye tracking. SCIENTIFIC REPORTS, v. 11, n. 1, . (11/50761-2, 14/50889-7, 20/01992-0)
BIOCCA, N.; BLANCO, P. J.; CABALLERO, D. E.; GIMENEZ, J. M.; CARR, G. E.; URQUIZA, S. A.. biologically-inspired mesh optimizer based on pseudo-material remodelin. COMPUTATIONAL MECHANICS, v. 69, n. 2, . (14/50889-7)
BLANCO, PABLO J.; BULANT, CARLOS A.; BEZERRA, CRISTIANO GUEDES; LEMOS, PEDRO A.; GARCIA-GARCIA, HECTOR M.. Simultaneous assessment of coronary stenosis relevance with automated computed tomography angiography and intravascular ultrasound analyses and fractional flow reserve. Coronary Artery Disease, v. 31, n. 1, p. 25-30, . (14/50889-7)
BORGES, LUCAS R.; BROCHI, MARCO A. C.; XU, ZHONGWEI; FOI, ALESSANDRO; VIEIRA, MARCELO A. C.; AZEVEDO-MARQUES, PAULO M.. Noise modeling and variance stabilization of a computed radiography (CR) mammography system subject to fixed-pattern noise. Physics in Medicine and Biology, v. 65, n. 22, . (14/50889-7, 18/19888-5)
CARDOSO, THIAGO, V; MICHELASSI, GABRIEL C.; FRANCO, FELIPE O.; SUMIYA, FERNANDO M.; PORTOLESE, JOANA; BRENTANI, HELENA; MACHADO-LIMA, ARIANE; NUNES, FATIMA L. S.; ALMEIDA, JR; GONZALEZ, AR; et al. Autism Spectrum Disorder diagnosis based on trajectories of eye tracking data. 2021 IEEE 34TH INTERNATIONAL SYMPOSIUM ON COMPUTER-BASED MEDICAL SYSTEMS (CBMS), v. N/A, p. 6-pg., . (20/01992-0, 14/50889-7)

Please report errors in scientific publications list using this form.