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National Institute of Science and Technology in Cell Therapy

Grant number: 08/57877-3
Support type:Research Projects - Thematic Grants
Duration: March 01, 2009 - July 31, 2016
Field of knowledge:Health Sciences - Medicine
Cooperation agreement: CNPq - INCTs
Principal Investigator:Roberto Passetto Falcão
Grantee:Roberto Passetto Falcão
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated grant(s):12/50947-1 - Studies of genetic and epigenetic mechanisms in telomere associated genes: their clinical importance in lymphoid malignancies, AP.R
Associated scholarship(s):11/15416-2 - Retrospective prospecting of lipids present in follicular fluid associated with the development potential of oocytes, BP.MS


Cell therapy is the use of cells for therapeutically objectives. These cells can be used systemically or locally in affected tissues or organs. The cells also vary with regard to the state of maturation and differentiation. Examples of successful stem cell (SC) therapies have appeared in recent years and the search for new therapies has brought new hope for the treatment of some illnesses. Success in the development of new cell therapies starts with an effort in basic research to isolate characterize and understand the biological mechanisms Involved In the maintenance of an undifferentiated state by the stem cell. The second step specifically comprehends the establishment of homogeneous and well characterized SC Iines, deposited in SC banks created for this purpose and responsible for the stock, propagation and distribution of these lines for the laboratories. The third step consists of the large scaled production of well characterized SC to be used in pre-clinical and clinical studies. Finally, the fourth stage involves pre-clinical and clinical studies which demand a specialized physical and professional structure. The present proposal for the creation of a National Institute of Science and Technology in Cell Therapy (INCTC) Is based on the consideration thus the INCTC intends to develop an extensive program of basic and clinical research, reaching all four phases described above. This challenge can only be accomplished by orchestrated efforts of already experienced groups in this area, which can focus on studies in stem cell therapy to advance in the area and to place the country in conditions of equality with the leading countries in this area. The INCTC congregate the eight year experience of the Center for Cell Based Therapy (CTC _ USP/Ribeirão Preto), one of the CEPIDS of FAPESP, together with the experience of four more groups long dedicated to the subject: the group of Lygia da Veiga Pereira (IB/USP), Maria Angélica Miglino (FMVZ/USP), Flávio Meirelles (FZEA/USP) and Stevens Rehen (UFRJ). A fifth group enters in the quality of Supported Emergent Center (National Center of Primates of Belém - Pará). This research team possesses the extensive proven and complementary and quality production in experience that fully justifies the working premises for the establishment of a research network under the proposal of the national institutes. The work proposed for the INCTC is contains by three main components: the scientific research program, ample educational activities and the program for transference of knowledge and innovation to public or private entitles. The scientific program consistent of 30 articulated subprojects that, in summary, intend to: isolate, characterize, understand, cultivate, amplify, test in animal models, and clinically use stem cells from diverse sources. We intend to carry out intense activities of knowledge transference society involving the general public, professors of basic education (secondary good) and their students. We intend to extend the activities already carried out by the CTC-CEPID, extending them to the cities of the associated laboratories (São Paulo, Pirassununga, Rio de Janeiro and Belém) proposing new activities to reach more people. We propose to enlarge up these initiatives by means of specialization courses through the internet, using the TIDIA platform, as part of the program of the Virtual University of the State of São Paulo (UNIVESP) which may be eventually extended throughout Brazil. Furthermore we intend to structure and implement post-graduation courses (strictu and latu) both, for scientific formation and for the popularization science. Finally, in regard to activities related to innovation, we intend to extend the successful experience of the CTC-CEPID that created a incubator for companies in side its main search building (CRH-HCFMRP-USP), with the objective to support entrepreneurs in the areas of biotechnology and biomedicine. This incubator (INBIOS) was created in 2002 and, in 2006, joined SUPERA (Incubator of Companies with Technological Base of Ribeirão Preto). (AU)

Scientific publications (11)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DAVANSO, MARIANA RODRIGUES; CALIARI-OLIVEIRA, CAROLINA; BARRA COURI, CARLOS EDUARDO; COVAS, DIMAS TADEU; DE OLIVEIRA LEAL, ANGELA MERICE; VOLTARELLI, JULIO CESAR; RIBEIRO MALMEGRIM, KELEN CRISTINA; UEDA YAOCHITE, JULIANA NAVARRO. DPP-4 Inhibition Leads to Decreased Pancreatic Inflammatory Profile and Increased Frequency of Regulatory T Cells in Experimental Type 1 Diabetes. Inflammation, v. 42, n. 2, p. 449-462, APR 2019. Web of Science Citations: 0.
DE OLIVEIRA, G. L. V.; FERREIRA, A. F.; GASPAROTTO, E. P. L.; KASHIMA, S.; COVAS, D. T.; GUERREIRO, C. T.; BRUM, D. G.; BARREIRA, A. A.; VOLTARELLI, J. C.; SIMOES, B. P.; OLIVEIRA, M. C.; DE CASTRO, F. A.; MALMEGRIM, K. C. R. Defective expression of apoptosis-related molecules in multiple sclerosis patients is normalized early after autologous haematopoietic stem cell transplantation. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, v. 187, n. 3, p. 383-398, MAR 2017. Web of Science Citations: 4.
ARRUDA, LUCAS C. M.; DE AZEVEDO, JULIA T. C.; DE OLIVEIRA, GISLANE L. V.; SCORTEGAGNA, GABRIELA T.; RODRIGUES, EVANDRA S.; PALMA, PATRICIA V. B.; BRUM, DORALINA G.; GUERREIRO, CARLOS T.; MARQUES, VANESSA D.; BARREIRA, AMILTON A.; COVAS, DIMAS T.; SIMOES, BELINDA P.; VOLTARELLI, JULIO C.; OLIVEIRA, MARIA CAROLINA; MALMEGRIM, KELEN C. R. Immunological correlates of favorable long-term clinical outcome in multiple sclerosis patients after autologous hematopoietic stem cell transplantation. Clinical Immunology, v. 169, p. 47-57, AUG 2016. Web of Science Citations: 16.
UEDA YAOCHITE, JULIANA NAVARRO; ALVES DE LIMA, KALIL WILLIAN; CALIARI-OLIVEIRA, CAROLINA; BONINI PALMA, PATRICIA VIANNA; BARRA COURI, CARLOS EDUARDO; SIMOES, BELINDA PINTO; COVAS, DIMAS TADEU; VOLTARELLI, JULIO CESAR; OLIVEIRA, MARIA CAROLINA; DONADI, EDUARDO ANTONIO; RIBEIRO MALMEGRIM, KELEN CRISTINA. Multipotent mesenchymal stromal cells from patients with newly diagnosed type 1 diabetes mellitus exhibit preserved in vitro and in vivo immunomodulatory properties. STEM CELL RESEARCH & THERAPY, v. 7, JAN 18 2016. Web of Science Citations: 20.
DE ARAUJO, LUIZA F.; FONSECA, ALINE S.; MUYS, BRUNA R.; PLACA, JESSICA R.; BUENO, RAFAELA B. L.; LORENZI, JULIO C. C.; SANTOS, ANEMARI R. D.; MOLFETTA, GREICE A.; ZANETTE, DALILA L.; SOUZA, JORGE E. S.; VALENTE, VALERIA; SILVA, JR., WILSON A. Mitochondrial genome instability in colorectal adenoma and adenocarcinoma. TUMOR BIOLOGY, v. 36, n. 11, p. 8869-8879, NOV 2015. Web of Science Citations: 10.
BRESSAN, FABIANA FERNANDES; FANTINATO-NETO, PAULO; ANDRADE, GABRIELLA MAMEDE; SANGALLI, JULIANO RODRIGUES; SAMPAIO, RAFAEL VILAR; DA SILVEIRA, JULIANO COELHO; PERECIN, FELIPE; MEIRELLES, FLAVIO VIEIRA. Challenges and perspectives to enhance cattle production via in vitro techniques: focus on epigenetics and cell-secreted vesicles. Ciência Rural, v. 45, n. 10, p. 1879-1886, OCT 2015. Web of Science Citations: 1.
CASTILHO-FERNANDES, ANDRIELLE; FONTES, APARECIDA MARIA; ABRAHAM, KURUVILLA JOSEPH; CORREA DE FREITAS, MARCELA CRISTINA; DA ROSA, NATHALIA GONSALES; PICANCO-CASTRO, VIRGINIA; DE SOUSA RUSSO-CARBOLANTE, ELISA MARIA; COVAS, DIMAS TADEU. Significant differences in integration sites of Moloney murine leukemia virus/Moloney murine sarcoma virus retroviral vector carrying recombinant coagulation factor IX in two human cell lines. Biotechnology Letters, v. 37, n. 5, p. 991-1001, MAY 2015. Web of Science Citations: 0.
UEDA YAOCHITE, JULIANA NAVARRO; CALIARI-OLIVEIRA, CAROLINA; BOTELHO DE SOUZA, LUCAS EDUARDO; NETO, LOURENCO SBRAGIA; BONINI PALMA, PATRICIA VIANNA; COVAS, DIMAS TADEU; RIBEIRO MALMEGRIM, KELEN CRISTINA; VOLTARELLI, JULIO CESAR; DONADI, EDUARDO ANTONIO. Therapeutic efficacy and biodistribution of allogeneic mesenchymal stem cells delivered by intrasplenic and intrapancreatic routes in streptozotocin-induced diabetic mice. STEM CELL RESEARCH & THERAPY, v. 6, MAR 14 2015. Web of Science Citations: 16.
BRESSAN, FABIANA F.; SANGALLI, JULIANO R.; PESSA, LAIS V. F.; PIRES, PEDRO R. L.; MEIRELLES, FLAVIO V. Insights on bovine genetic engineering and cloning. Pesquisa Veterinária Brasileira, v. 33, n. 1, p. 113-118, DEC 2013. Web of Science Citations: 1.
FONTES, A. M.; MELO, F. U. F.; GREENE, L. J.; FACA, V. M.; LIN, Y.; GERSON, S. L.; COVAS, D. T. Production of human factor VIII-FL in 293T cells using the bicistronic MGMT(P140K)-retroviral vector. Genetics and Molecular Research, v. 11, n. 1, p. 775-789, 2012. Web of Science Citations: 2.

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