Synthesis, spectroscopic characterization and in vitro antibacterial and antiviral activities of novel silver(I) complexes with mafenide and ethyl-mafenide

Autor(es):Mostrar menos -

Esquezaro, Pedro Goncalves ^[1] ; Manzano, Carlos Marrote ^[1] ; Nakahata, Douglas Hideki ^{[1, 2]} ; Santos, Igor Andrade ^[3] ; Aquino Ruiz, Uriel Enrique ^[3] ; Santiago, Mariana Brentini ^[4] ; Souza Silva, Nagela Bernadelli ^[4] ; Gomes Martins, Carlos Henrique ^[4] ; Pereira, Douglas Henrique ^[5] ; Goulart Bergamini, Fernando Rodrigues ^[6] ; Gomes Jardim, Ana Carolina ^[3] ; Corbi, Pedro Paulo ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Inst Chem, UNICAMP, POB 6154, BR-13083970 Campinas, SP - Brazil

^[2] Fed Univ Goias UFG, Inst Chem, BR-74690900 Goiania, Go - Brazil

^[3] Fed Univ Uberlandia UFU, Inst Biomed Sci, Lab Virol, BR-38405302 Uberlandia, MG - Brazil

^[4] Fed Univ Uberlandia UFU, Inst Biomed Sci, Lab Antimicrobial Testing, BR-38405302 Uberlandia, MG - Brazil

^[5] Fed Univ Tocantins UFT, Chem Coll, POB 66, BR-77402970 Gurupi, TO - Brazil

^[6] Fed Univ Uberlandia UFU, Inst Chem, Lab Synth Bioinspired Mol, BR-38400902 Uberlandia, MG - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Molecular Structure; v. 1246, DEC 15 2021.
• Citações Web of Science: 0

Resumo

Two novel silver(I) complexes with the antibacterial sulfa drugs mafenide (Maf) and ethyl-mafenide (eMaf) are presented in this article. Elemental analysis indicated the 1:1 metal:ligand compositions AgC7H9N2O2S for Ag-Maf and AgC8H11N2O2S for Ag-eMaf. Infrared (IR), and H-1 and C-13 nuclear magnetic resonance (NMR) spectroscopic analyses indicated coordination of the sulfa drugs to silver(I) by the nitrogen and oxygen atoms of the deprotonated sulfonamide (SO2NH) group in a bidentate chelate mode. The proposition of the coordination mode of the sulfa drugs to silver(I) was also supported by a combination of experimental and theoretical (DFT) data. The Ag-Maf and Ag-eMaf complexes exhibited antibacterial activity over Staphylococcus aureus, Burkholderia cepacia, Staphylococcus epidermidis, and Pseudomonas aeruginosa aerobic bacteria , with MIC (minimum inhibitory concentration) in the range 21.3-170 mu mol L-1, being comparable to the commercial drug silver-sulfadiazine (SSD). Antiviral studies against Chikungunya virus (CHIKV) showed that the complexes exhibit anti-CHIKV activity at non-cytotoxic concentrations to the host cells. Biophysical studies based on gel electrophoresis indicated that the complexes do not interact with albumin and lysozyme, which suggests that proteins are not the main targets of the compounds. (C) 2021 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 18/12062-4 - Síntese, caracterização e estudos de interação com biomoléculas de complexos metálicos contendo ligantes biologicamente ativos: uma estratégia na preparação de novos agentes com atividades antibacterianas e antivirais
• Beneficiário: Pedro Paulo Corbi
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/25995-6 - Novos complexos metálicos de Ag(I), Pd(II) e Pt(II) com ligantes utilizados no tratamento da Tuberculose: síntese e avaliação in vitro das atividades antimicrobiana e antiproliferativa
• Beneficiário: Carlos Marrote Manzano
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 17/11485-6 - Desenvolvimentos computacionais e teóricos baseados em métodos ab initio e na Teoria do Funcional de Densidade
• Beneficiário: Rogério Custodio
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/08293-7 - CECC - Centro de Engenharia e Ciências Computacionais
• Beneficiário: Munir Salomao Skaf
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs