The effect of lyophilized platelet rich-plasma on skin aging: a non-randomized, controlled, pilot trial

Autor(es)

da Silva, Leticia Queiroz ^[1] ; Cancela, Rebeca Brito Bonani ^[1] ; de Lima Montalvao, Silmara Aparecida ^[1] ; Huber, Stephany Cares ^[1] ; Vieira-Damiani, Gislaine ^[2] ; Triglia, Renata Marchi ^[3] ; Annichino-Bizzacchi, Joyce Maria ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Hemostasis Lab, Hemoctr, 480 Carlos Chagas St, Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Sch Med Sci, Dept Med, 126 Tessalia Vieira Camargo St, Campinas, SP - Brazil

^[3] Univ Estadual Campinas, Hosp Clin, Dept Pathol Anat, 251 Vital Brazil St, Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ARCHIVES OF DERMATOLOGICAL RESEARCH; v. 313, n. 10, p. 863-871, DEC 2021.
• Citações Web of Science: 2

Resumo

Platelet-rich plasma (PRP) showed positive results in the improvement of skin aging. Lyophilized PRP can be interesting in clinical practice due to the facility to obtain many samples in a single blood collection and can be used in multiple injections. To evaluate the effect of lyophilized PRP in the treatment of skin aging, through a Phase II pilot study. Nineteen women (54 years +/- 7 years) with Glogau photoaging II and III types were select for this non-randomized, split-face controlled study. They received monthly intradermal injections of lyophilized PRP and saline solution (as control) into the facial skin, during a period of 2 months. The evaluation was performed by imaging method, histological techniques, and multiphoton microscopy. Although lyophilized PRP presented 10 times the platelet baseline value (P < .0001) and growth factors in adequate levels, only saline solution showed an increase of dermis thickness (p = .0009). Collagen pre and post-application remained the same for both types of treatments. The use of lyophilized PRP by mesotherapy showed no improvement on skin aging. (AU)

• Processo FAPESP: 16/14172-6 - Investigação de aspectos fisiopatológicos e novas abordagens terapêuticas em doenças tromboembólicas
• Beneficiário: Joyce Maria Annichino-Bizzacchi
• Modalidade de apoio: Auxílio à Pesquisa - Temático