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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The effect of lyophilized platelet rich-plasma on skin aging: a non-randomized, controlled, pilot trial

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Author(s):
da Silva, Leticia Queiroz [1] ; Cancela, Rebeca Brito Bonani [1] ; de Lima Montalvao, Silmara Aparecida [1] ; Huber, Stephany Cares [1] ; Vieira-Damiani, Gislaine [2] ; Triglia, Renata Marchi [3] ; Annichino-Bizzacchi, Joyce Maria [1]
Total Authors: 7
Affiliation:
[1] Univ Estadual Campinas, Hemostasis Lab, Hemoctr, 480 Carlos Chagas St, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Sch Med Sci, Dept Med, 126 Tessalia Vieira Camargo St, Campinas, SP - Brazil
[3] Univ Estadual Campinas, Hosp Clin, Dept Pathol Anat, 251 Vital Brazil St, Campinas, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: ARCHIVES OF DERMATOLOGICAL RESEARCH; v. 313, n. 10, p. 863-871, DEC 2021.
Web of Science Citations: 2
Abstract

Platelet-rich plasma (PRP) showed positive results in the improvement of skin aging. Lyophilized PRP can be interesting in clinical practice due to the facility to obtain many samples in a single blood collection and can be used in multiple injections. To evaluate the effect of lyophilized PRP in the treatment of skin aging, through a Phase II pilot study. Nineteen women (54 years +/- 7 years) with Glogau photoaging II and III types were select for this non-randomized, split-face controlled study. They received monthly intradermal injections of lyophilized PRP and saline solution (as control) into the facial skin, during a period of 2 months. The evaluation was performed by imaging method, histological techniques, and multiphoton microscopy. Although lyophilized PRP presented 10 times the platelet baseline value (P < .0001) and growth factors in adequate levels, only saline solution showed an increase of dermis thickness (p = .0009). Collagen pre and post-application remained the same for both types of treatments. The use of lyophilized PRP by mesotherapy showed no improvement on skin aging. (AU)

FAPESP's process: 16/14172-6 - Investigation of the pathophysiological aspects and novel therapeutic approaches for thromboembolic disorders
Grantee:Joyce Maria Annichino-Bizzacchi
Support Opportunities: Research Projects - Thematic Grants