Reproductive and endocrinological effects of Benign Prostatic Hyperplasia and finasteride therapy in dogs

Autor(es)

Angrimani, Daniel S. R. ^[1] ; Brito, Maira M. ^[1] ; Rui, Bruno R. ^[1] ; Nichi, Marcilio ^[1] ; Vannucchi, Camila I. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Anim Reprod, Av Prof Orlando Marques de Paiva 87, BR-05508270 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 10, n. 1 SEP 9 2020.
• Citações Web of Science: 1

Resumo

Benign prostatic hyperplasia (BPH) is one of the most important reproductive disorders in aging dogs. Therapeutic measures include orchiectomy and pharmacological treatment, leading to reduction of prostate volume and clinical signs. One of the most common drugs used in BPH treatment is finasteride, but data regarding its possible side effects are scarce. Thus, the aim of this study was to evaluate the effects of BPH and short-term (2 months) finasteride therapy on clinical, endocrinological, and reproductive parameters in dogs. Dogs were allocated into four experimental groups: Non-affected (n=5), BPH (n=5), Non-Affected-Finasteride (n=5) and BPH-Finasteride (n=5) groups. Dogs were evaluated monthly during 2 months by a complete breeding soundness examination, B-mode ultrasound and Doppler ultrasonography of the testicular artery, hormonal profile (testosterone, estrogen and dihydrotestosterone) and oxidative profile of the prostatic fluid. After 2 months, dogs were gonadectomized and testicles were subjected to histologic analysis. Finasteride treatment reduced dihydrotestosterone concentrations, without negative influence on semen quality and also reverted testicular hemodynamics changes of BPH. On the other hand, BPH was accompanied by significant changes in testosterone and estrogen concentrations and semen quality, mainly related to sperm kinetics alterations. In conclusion, BPH dogs have important hormonal and sperm alterations, however, short-term finasteride treatment (2 months) was able to reduce overall effects of BPH, thus representing a method of therapy for BPH treatment. (AU)

• Processo FAPESP: 15/05419-5 - Senescência reprodutiva em cães: aspectos clínicos e biotecnológicos
• Beneficiário: Camila Infantosi Vannucchi
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/04102-3 - Influência da hiperplasia prostática benigna e tratamento com finasterida na integridade espermática de cães
• Beneficiário: Daniel de Souza Ramos Angrimani
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 13/25966-5 - Caracterização seminal e das alterações hemodinâmicas da próstata e testículos de cães com hiperplasia prostática benigna
• Beneficiário: Daniel de Souza Ramos Angrimani
• Modalidade de apoio: Bolsas no Brasil - Doutorado