Biomarkers of human papillomavirus (HPV)-driven head and neck cancer in Latin America and Europe study: Study design and HPV DNA/p16(INK4a) status

Autor(es):Mostrar menos -

Sichero, Laura ^[1] ; Tagliabue, Marta ^[2] ; Mota, Giana ^[1] ; Ferreira, Silvaneide ^[1] ; Nunes, Rafaella A. L. ^[1] ; Castaneda, Carlos Arturo ^[3] ; Castillo, Miluska ^[4] ; Correa, Rita Mariel ^[5] ; Perdomo, Sandra ^{[6, 7]} ; Rodriguez-Urrego, Paula A. ^[6] ; Matos, Leandro Luongo ^[8] ; Mohssen, Ansarin ^[2] ; Gheit, Tarik ^[9] ; Tommasino, Massimo ^[9] ; Chiocca, Susanna ^[10] ; Villa, Luisa Lina ^{[11, 1]} ; Grp, HEADLAcE Study

Afiliação do(s) autor(es):Mostrar menos -

^[1] Hosp Clin Fac Med Univ Sao Paulo FMUSP HC, Inst Canc Estado Sao Paulo ICESP, Ctr Translat Res Oncol, Sao Paulo - Brazil

^[2] IRCCS, European Inst Oncol, Div Otolaryngol Head & Neck Surg, Milan - Italy

^[3] Inst Nacl Enfermedades Neoplasicas, Dept Med Oncol, Lima - Peru

^[4] Inst Nacl Enfermedades Neoplasicas, Dept Res, Lima - Peru

^[5] ANLIS Dr Malbran, Inst Nacl Enfermedades Infecc, Serv Virus Oncogen, Buenos Aires, DF - Argentina

^[6] Univ Hosp Fdn Santa Fe Bogot, Bogota - Colombia

^[7] Int Agcy Res Canc IARC, Genom Epidemiol Branch, Lyon - France

^[8] Univ Sao Paulo, Fac Med, Dept Head & Neck Surg, Sao Paulo - Brazil

^[9] Int Agcy Res Canc IARC, Infect & Canc Biol Grp, Lyon - France

^[10] IRCCS, European Inst Oncol, Dept Expt Oncol, Milan - Italy

^[11] Univ Sao Paulo, Fac Med, Dept Radiol & Oncol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK; v. 44, n. 1 NOV 2021.
• Citações Web of Science: 0

Resumo

Background Human papillomavirus (HPV)-driven head/neck squamous cell carcinomas (HNSCC) prevalence varies globally. We evaluated HPV DNA and p16(INK4a) in formalin fixed paraffin embedded (FFPE) HNSCC from Argentina, Brazil, Colombia, and Peru. Methods HPV was genotyped by PCR-hybridization. All HPV DNA positive and some HPV DNA negative cases underwent p16(INK4a) immunohistochemistry. Results HPV DNA was detected in 32.8%, 11.1%, and 17.8% of oropharyngeal (OPC), oral cavity (OCC) and laryngeal (LC) cancers, respectively. OPC HPV prevalence was higher in Colombia (94.7%), and Argentina (42.6%) compared to Brazil (10.6%) and Peru (0.0%). HPV-16 was the most detected. Other HPVs were found in LC. Higher rates of p16(INK4a) positivity were observed among HPV positive OPC/OCC cases compared to LC cases. Conclusions Our results support a role for HPV-16 in a subset of HNSCC, corroborate the heterogeneity observed in samples from different countries, and contribute additional etiological and biomarkers information in tumors of significant impact worldwide. (AU)

• Processo FAPESP: 17/04020-7 - Biomarcadores de tumores de cabeça e pescoço induzidos por HPV na América Latina e Europa
• Beneficiário: Luisa Lina Villa
• Modalidade de apoio: Auxílio à Pesquisa - Regular