Stability of SARS-CoV-2 and other airborne viruses under different stress conditions

Autor(es)

Fumagalli, Marcilio Jorge ^[1] ; Capato, Carlos Fabiano ^[1] ; de Castro-Jorge, Luiza Antunes ^[1] ; de Souza, William Marciel ^[1] ; Arruda, Eurico ^[1] ; Figueiredo, Luiz Tadeu Moraes ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Virol Res Ctr, Av Bandeirantes 3900, BR-14049090 Ribeirao Preto - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ARCHIVES OF VIROLOGY; v. 167, n. 1 NOV 2021.
• Citações Web of Science: 0

Resumo

Viral stability under stress conditions may directly affect viral dissemination, seasonality, and pathogenesis. We exposed airborne viruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), mumps virus, coxsackievirus B5, human rhinovirus A16, and respiratory syncytial virus, to different temperatures, UV light exposure time, pH values, and osmotic pressures and measured the remaining viral infectivity. Reduced thermal stability was observed for coxsackievirus B5 at 45 degrees C, while SARS-CoV-2 demonstrated residual infectivity at 55 degrees C. UV light exposure was an efficient means of viral inactivation but was less efficient for non-enveloped viruses. Rhinovirus A16 and respiratory syncytial virus demonstrated extreme sensitivity to acid conditions, while SARS-CoV-2, rhinovirus A16, and respiratory syncytial virus were unstable in an alkaline environment. The information obtained in this study will be useful for the development of viral inactivation methods and may be correlated with epidemiological and seasonal viral characteristics. (AU)

• Processo FAPESP: 18/09383-3 - Estudo sobre epitopos de Flavivirus com importância médica no Brasil e de seus anticorpos
• Beneficiário: Marcilio Jorge Fumagalli
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 19/26119-0 - Vírus emergentes e reemergentes: biologia, patogênese e prospecção
• Beneficiário: Eurico de Arruda Neto
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 19/27333-6 - Fisiopatologia e diagnóstico das infecções por alphavírus artritogênicos
• Beneficiário: Luiz Tadeu Moraes Figueiredo
• Modalidade de apoio: Auxílio à Pesquisa - Regular