Skeletal muscle histidine-containing dipeptide contents are increased in freshwater turtles (C. picta bellii) with cold-acclimation

Autor(es)

Dolan, Eimear ^[1] ; Warren, Daniel E. ^[2] ; Harris, Roger C. ^[3] ; Sale, Craig ^[4] ; Gualano, Bruno ^{[5, 1]} ; Saunders, Bryan ^{[6, 1]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med FMUSP, Sch Phys Educ & Sport, Rheumatol Div, Appl Physiol & Nutr Res Grp, Sao Paulo, SP - Brazil

^[2] St Louis Univ, Dept Biol, St Louis, MO 63103 - USA

^[3] Junipa Ltd, Newmarket, Suffolk - England

^[4] Nottingham Trent Univ, Sport Hlth & Performance Enhancement Res Ctr, Sch Sci & Technol, Musculoskeletal Physiol Res Grp, Nottingham - England

^[5] Univ Sao Paulo, Food Res Ctr, Sao Paulo - Brazil

^[6] Univ Sao Paulo, Fac Med FMUSP, Inst Orthopaed & Traumatol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY; v. 262, DEC 2021.
• Citações Web of Science: 0

Resumo

Freshwater turtles found in higher latitudes can experience extreme challenges to acid-base homeostasis while overwintering, due to a combination of cold temperatures along with the potential for environmental hypoxia. Histidine-containing dipeptides (HCDs; carnosine, anserine and balenine) may facilitate pH regulation in response to these challenges, through their role as pH buffers. We measured the HCD content of three tissues (liver, cardiac and skeletal muscle) from the anoxia-tolerant painted turtle (C. picta bellii) acclimated to either 3 or 20 degrees C. HCDs were detected in all tissues, with the highest content shown in the skeletal muscle. Turtles acclimated to 3 degrees C had more HCD in their skeletal muscle than those acclimated to 20 degrees C (carnosine = 20.8 +/- 4.5 vs 12.5 +/- 5.9 mmol. kg DM-1; ES = 1.59 (95%CI: 0.16-3.00), P = 0.013). The higher HCD content shown in the skeletal muscle of the cold-acclimated turtles suggests a role in acid-base regulation in response to physiological challenges associated with living in the cold, with the increase possibly related to the temperature sensitivity of carnosine's dissociation constant. (AU)

• Processo FAPESP: 19/26899-6 - A resposta óssea ao exercício: um programa de pesquisa translacional explorando aspectos clínicos e mecanísticos
• Beneficiário: Eimear Bernadette Dolan
• Modalidade de apoio: Bolsas no Brasil - Jovens Pesquisadores
• Processo FAPESP: 17/13552-2 - Reduzindo tempo sedentário em populações clínicas: o estudo take a stand for health
• Beneficiário: Bruno Gualano
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 16/50438-0 - Suplementação nutricional e exercício para otimizar o desempenho: foco nas respostas individuais e um passo para a nutrição esportiva personalizada
• Beneficiário: Bryan Saunders
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 19/05616-6 - A resposta óssea ao exercício: um programa de pesquisa translacional explorando aspectos clínicos e mecanísticos
• Beneficiário: Eimear Bernadette Dolan
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores