AD-Related CSF Biomarkers Across Distinct Levels of Cognitive Impairment: Correlations With Global Cognitive State

Autor(es)

Ibarra, Romel ^[1] ; Radanovic, Marcia ^[1] ; Pais, V, Marcos ; Talib, Leda L. ^[2] ; Forlenza, V, Orestes

Afiliação do(s) autor(es)

^[1] V, Univ Sao Paulo, Hosp Clin HCFMUSP, Dept & Inst Psiquiatria, Lab Neurociencias LIM 27, Fac Med, Sao Paulo - Brazil

^[2] Pais, Marcos, V, V, Univ Sao Paulo, Hosp Clin HCFMUSP, Dept & Inst Psiquiatria, Lab Neurociencias LIM 27, Fac Med, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY; v. 34, n. 6, SI, p. 659-667, NOV 2021.
• Citações Web of Science: 1

Resumo

Aim: Associations between cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) with the severity of cognitive impairment are unclear. We examined the correlations between CSF biomarkers and cognitive performance in the AD continuum. Methods: We studied 143 elderly patients: cognitively unimpaired (n = 51), mild cognitive impairment (MCI) amnestic (n = 55) and nonamnestic (n = 20), and mild AD (n = 17) assessed with the Cambridge Cognitive Test (CAMCOG). We correlated total CAMCOG and its subdomains with CSF A beta 42, T-tau, p-tau levels, and A beta 42/p-tau. Results: In the total sample, T-tau and A beta 42/p-tau correlated with the total CAMCOG (P< .01); all biomarkers correlated with memory (P< .001); T-tau correlated with language (P< .01). Conclusion: Memory and T-tau levels may be the most suitable parameters to reflect cognitive/CSF biomarker correlations. At present, such correlations are of little use in routine clinical practice. (AU)

• Processo FAPESP: 09/52825-8 - Neurobiologia da doença de Alzheimer: marcadores de risco, prognóstico e resposta terapêutica
• Beneficiário: Wagner Farid Gattaz
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 16/01302-9 - Identificação das vias direta e indireta da inibição da glicogênio sintase kinase 3B pelo lítio em cultura de neurônios
• Beneficiário: Vanessa de Jesus Rodrigues de Paula
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 14/14211-6 - Comprimento telomérico no sistema nervoso central de um modelo de Doença de Alzheimer tratado com lítio
• Beneficiário: Giancarlo de Mattos Cardillo
• Modalidade de apoio: Bolsas no Brasil - Mestrado