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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

AD-Related CSF Biomarkers Across Distinct Levels of Cognitive Impairment: Correlations With Global Cognitive State

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Author(s):
Ibarra, Romel [1] ; Radanovic, Marcia [1] ; Pais, V, Marcos ; Talib, Leda L. [2] ; Forlenza, V, Orestes
Total Authors: 5
Affiliation:
[1] V, Univ Sao Paulo, Hosp Clin HCFMUSP, Dept & Inst Psiquiatria, Lab Neurociencias LIM 27, Fac Med, Sao Paulo - Brazil
[2] Pais, Marcos, V, V, Univ Sao Paulo, Hosp Clin HCFMUSP, Dept & Inst Psiquiatria, Lab Neurociencias LIM 27, Fac Med, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY; v. 34, n. 6, SI, p. 659-667, NOV 2021.
Web of Science Citations: 1
Abstract

Aim: Associations between cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) with the severity of cognitive impairment are unclear. We examined the correlations between CSF biomarkers and cognitive performance in the AD continuum. Methods: We studied 143 elderly patients: cognitively unimpaired (n = 51), mild cognitive impairment (MCI) amnestic (n = 55) and nonamnestic (n = 20), and mild AD (n = 17) assessed with the Cambridge Cognitive Test (CAMCOG). We correlated total CAMCOG and its subdomains with CSF A beta 42, T-tau, p-tau levels, and A beta 42/p-tau. Results: In the total sample, T-tau and A beta 42/p-tau correlated with the total CAMCOG (P< .01); all biomarkers correlated with memory (P< .001); T-tau correlated with language (P< .01). Conclusion: Memory and T-tau levels may be the most suitable parameters to reflect cognitive/CSF biomarker correlations. At present, such correlations are of little use in routine clinical practice. (AU)

FAPESP's process: 09/52825-8 - Neurobiology of Alzheimer's disease: risk markers, prognosis and therapeutic response
Grantee:Wagner Farid Gattaz
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 16/01302-9 - Direct and indirect pathways of glycogen synthase kinase 3B inhibition by lithium in culture of neurons
Grantee:Vanessa de Jesus Rodrigues de Paula
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 14/14211-6 - Telomere length in the central nervous system of a model of Alzheimer's Disease treated with lithium
Grantee:Giancarlo de Mattos Cardillo
Support Opportunities: Scholarships in Brazil - Master