Acute cardiometabolic effects of brief active breaks in sitting for patients with rheumatoid arthritis

Autor(es):Mostrar menos -

Pinto, Ana J. ^[1] ; Meireles, Kamila ^[1] ; Pecanha, Tiago ^[1] ; Mazzolani, Bruna C. ^[1] ; Smaira, I, Fabiana ; Rezende, Diego ^[2] ; Benatti, Fabiana B. ^{[3, 2]} ; Ribeiro, Ana C. M. ^[4] ; Pinto, Ana L. S. ^{[2, 4]} ; Lima, Fernanda R. ^{[2, 4]} ; Shinjo, Samuel K. ^[4] ; Dantas, Wagner S. ^[5] ; Mellett, Natalie A. ^{[6, 7, 8]} ; Meikle, Peter J. ^{[6, 7, 8]} ; Owen, Neville ^{[9, 6, 7, 8]} ; Dunstan, David W. ^{[10, 6, 7, 8]} ; Roschel, Hamilton ^{[3, 2]} ; Gualano, Bruno ^{[3, 11, 2]}

Afiliação do(s) autor(es):Mostrar menos -

^[1] Univ Sao Paulo, Fac Med FMUSP, Sch Phys Educ & Sport, Lab Assessment & Conditioning Rheumatol, Appl Phys, Sao Paulo - Brazil

^[2] Smaira, Fabiana, I, Univ Sao Paulo, Fac Med FMUSP, Sch Phys Educ & Sport, Lab Assessment & Conditioning Rheumatol, Appl Phys, Sao Paulo - Brazil

^[3] Univ Estadual Campinas, Sch Appl Sci, Limeira - Brazil

^[4] Univ Sao Paulo, Sch Med FMUSP, Rheumatol Div, Sao Paulo - Brazil

^[5] Louisiana State Univ, Pennington Biomed Res Ctr, Integrated Physiol & Mol Med Lab, Baton Rouge, LA 70808 - USA

^[6] Baker Heart & Diabet Inst, Phys Act Lab, Melbourne, Vic - Australia

^[7] Baker Heart & Diabet Inst, Behav Epidemiol Lab, Melbourne, Vic - Australia

^[8] Baker Heart & Diabet Inst, Metabol Lab, Melbourne, Vic - Australia

^[9] Swinburne Univ Technol, Ctr Urban Transit, Melbourne, Vic - Australia

^[10] Australian Catholic Univ, Mary MacKillop Inst Hlth Res, Melbourne, Vic - Australia

^[11] Univ Sao Paulo, Food Res Ctr, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM; v. 321, n. 6, p. E782-E794, DEC 2021.
• Citações Web of Science: 0

Resumo

Exercise is a treatment in rheumatoid arthritis, but participation in moderate-to-vigorous exercise is challenging for some patients. Light-intensity breaks in sitting could be a promising alternative. We compared the acute effects of active breaks in sitting with those of moderate-to-vigorous exercise on cardiometabolic risk markers in patients with rheumatoid arthritis. In a crossover fashion, 15 women with rheumatoid arthritis underwent three 8-h experimental conditions: prolonged sitting (SIT), 30-min bout of moderate-to-vigorous exercise followed by prolonged sitting (EX), and 3-min bouts of light-intensity walking every 30 min of sitting (BR). Postprandial glucose, insulin, c-peptide, triglycerides, cytokines, lipid classes/subclasses (lipidomics), and blood pressure responses were assessed. Muscle biopsies were collected following each session to assess targeted proteins/genes. Glucose {[}-28% in area under the curve (AUC), P = 0.036], insulin (-28% in AUC, P = 0.016), and c-peptide (-27% in AUC, P = 0.006) postprandial responses were attenuated in BR versus SIT, whereas only c-peptide was lower in EX versus SIT (-20% in AUC, P = 0.002). IL-1 beta decreased during BR, but increased during EX and SIT (P = 0.027 and P = 0.085, respectively). IL-1ra was increased during EX versus BR (P = 0.002). TNF-alpha concentrations decreased during BR versus EX (P = 0.022). EX, but not BR, reduced systolic blood pressure (P = 0.013). Lipidomic analysis showed that 7 of 36 lipid classes/subclasses were significantly different between conditions, with greater changes being observed in EX. No differences were observed for protein/gene expression. Brief active breaks in sitting can offset markers of cardiometabolic disturbance, which may be particularly useful for patients who may find it difficult to adhere to exercise. NEW \& NOTEWORTHY Exercise is a treatment in rheumatoid arthritis but is challenging for some patients. Light-intensity breaks in sitting could be a promising alternative. Our findings show beneficial, but differential, cardiometabolic effects of active breaks in sitting and exercise in patients with rheumatoid arthritis. Breaks in sitting mainly improved glycemic and inflammatory markers, whereas exercise improved lipidomic and hypotensive responses. Breaks in sitting show promise in offsetting aspects of cardiometabolic disturbance associated with prolonged sitting in rheumatoid arthritis. (AU)

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• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
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