Acute cardiometabolic effects of brief active breaks in sitting for patients with rheumatoid arthritis

Author(s):Show less -

Pinto, Ana J. ^[1] ; Meireles, Kamila ^[1] ; Pecanha, Tiago ^[1] ; Mazzolani, Bruna C. ^[1] ; Smaira, I, Fabiana ; Rezende, Diego ^[2] ; Benatti, Fabiana B. ^{[3, 2]} ; Ribeiro, Ana C. M. ^[4] ; Pinto, Ana L. S. ^{[2, 4]} ; Lima, Fernanda R. ^{[2, 4]} ; Shinjo, Samuel K. ^[4] ; Dantas, Wagner S. ^[5] ; Mellett, Natalie A. ^{[6, 7, 8]} ; Meikle, Peter J. ^{[6, 7, 8]} ; Owen, Neville ^{[9, 6, 7, 8]} ; Dunstan, David W. ^{[10, 6, 7, 8]} ; Roschel, Hamilton ^{[3, 2]} ; Gualano, Bruno ^{[3, 11, 2]}

Affiliation:Show less -

^[1] Univ Sao Paulo, Fac Med FMUSP, Sch Phys Educ & Sport, Lab Assessment & Conditioning Rheumatol, Appl Phys, Sao Paulo - Brazil

^[2] Smaira, Fabiana, I, Univ Sao Paulo, Fac Med FMUSP, Sch Phys Educ & Sport, Lab Assessment & Conditioning Rheumatol, Appl Phys, Sao Paulo - Brazil

^[3] Univ Estadual Campinas, Sch Appl Sci, Limeira - Brazil

^[4] Univ Sao Paulo, Sch Med FMUSP, Rheumatol Div, Sao Paulo - Brazil

^[5] Louisiana State Univ, Pennington Biomed Res Ctr, Integrated Physiol & Mol Med Lab, Baton Rouge, LA 70808 - USA

^[6] Baker Heart & Diabet Inst, Phys Act Lab, Melbourne, Vic - Australia

^[7] Baker Heart & Diabet Inst, Behav Epidemiol Lab, Melbourne, Vic - Australia

^[8] Baker Heart & Diabet Inst, Metabol Lab, Melbourne, Vic - Australia

^[9] Swinburne Univ Technol, Ctr Urban Transit, Melbourne, Vic - Australia

^[10] Australian Catholic Univ, Mary MacKillop Inst Hlth Res, Melbourne, Vic - Australia

^[11] Univ Sao Paulo, Food Res Ctr, Sao Paulo - Brazil

• Document type: Journal article
• Source: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM; v. 321, n. 6, p. E782-E794, DEC 2021.
• Web of Science Citations: 0

Abstract

Exercise is a treatment in rheumatoid arthritis, but participation in moderate-to-vigorous exercise is challenging for some patients. Light-intensity breaks in sitting could be a promising alternative. We compared the acute effects of active breaks in sitting with those of moderate-to-vigorous exercise on cardiometabolic risk markers in patients with rheumatoid arthritis. In a crossover fashion, 15 women with rheumatoid arthritis underwent three 8-h experimental conditions: prolonged sitting (SIT), 30-min bout of moderate-to-vigorous exercise followed by prolonged sitting (EX), and 3-min bouts of light-intensity walking every 30 min of sitting (BR). Postprandial glucose, insulin, c-peptide, triglycerides, cytokines, lipid classes/subclasses (lipidomics), and blood pressure responses were assessed. Muscle biopsies were collected following each session to assess targeted proteins/genes. Glucose {[}-28% in area under the curve (AUC), P = 0.036], insulin (-28% in AUC, P = 0.016), and c-peptide (-27% in AUC, P = 0.006) postprandial responses were attenuated in BR versus SIT, whereas only c-peptide was lower in EX versus SIT (-20% in AUC, P = 0.002). IL-1 beta decreased during BR, but increased during EX and SIT (P = 0.027 and P = 0.085, respectively). IL-1ra was increased during EX versus BR (P = 0.002). TNF-alpha concentrations decreased during BR versus EX (P = 0.022). EX, but not BR, reduced systolic blood pressure (P = 0.013). Lipidomic analysis showed that 7 of 36 lipid classes/subclasses were significantly different between conditions, with greater changes being observed in EX. No differences were observed for protein/gene expression. Brief active breaks in sitting can offset markers of cardiometabolic disturbance, which may be particularly useful for patients who may find it difficult to adhere to exercise. NEW \& NOTEWORTHY Exercise is a treatment in rheumatoid arthritis but is challenging for some patients. Light-intensity breaks in sitting could be a promising alternative. Our findings show beneficial, but differential, cardiometabolic effects of active breaks in sitting and exercise in patients with rheumatoid arthritis. Breaks in sitting mainly improved glycemic and inflammatory markers, whereas exercise improved lipidomic and hypotensive responses. Breaks in sitting show promise in offsetting aspects of cardiometabolic disturbance associated with prolonged sitting in rheumatoid arthritis. (AU)

• FAPESP's process: 19/14819-8 - Promotion of healthy lifestyle in patients with Systemic Lupus Erythematosus: assessment of safety, efficiency and feasibility of the study 'Vivendo bem com Lúpus' (Living well with Lupus)
• Grantee: Fabiana Infante Smaira
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 19/14820-6 - Healthy lifestyle promotion in patients with Systemic Lupus Erythematosus: effects on life quality and psychological aspects
• Grantee: Bruna Caruso Mazzolani
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 17/13552-2 - Reducing sedentary time in clinical populations: the take a stand for health study
• Grantee: Bruno Gualano
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 16/23319-0 - Cardiovascular autonomic dysfunction in rheumatoid arthritis patients: characterization, associations with the disease and effects of breaks in sedentary time
• Grantee: Tiago Peçanha de Oliveira
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 15/26937-4 - Studies on physical (in)activity in patients with rheumatoid arthritis: characterization, associations with disease and effects of breaking up sedentary time
• Grantee: Ana Jéssica Pinto
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 18/19418-9 - Acute and chronic effects of reducing sedentary time in rheumatoid arthritis: the Take a stand for health study
• Grantee: Ana Jéssica Pinto
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate (Direct)