| Texto completo | |
| Autor(es): |
Caetano, Lhiri Hanna De Lucca
[1]
;
Nishiyama-Jr, Milton Yutaka
;
Tavora, Bianca de Carvalho Lins Fernandes
[1]
;
de Oliveira, Ursula Castro
[2]
;
Junqueira-de-Azevedo, Inacio de Loiola Meirelles
[2]
;
Faquim-Mauro, Eliana L.
[1]
;
Magalhaes, Geraldo Santana
[1]
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] Inst Butantan, Lab Imunopatol, BR-05503900 Sao Paulo - Brazil
[2] Nishiyama-Jr, Jr., Milton Yutaka, Inst Butantan, Lab Toxinol Aplicada, BR-05503900 Sao Paulo - Brazil
Número total de Afiliações: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | TOXINS; v. 13, n. 12 DEC 2021. |
| Citações Web of Science: | 0 |
| Resumo | |
Among the Chilopoda class of centipede, the Cryptops genus is one of the most associated with envenomation in humans in the metropolitan region of the state of Sao Paulo. To date, there is no study in the literature about the toxins present in its venom. Thus, in this work, a transcriptomic characterization of the Cryptops iheringi venom gland, as well as a proteomic analysis of its venom, were performed to obtain a toxin profile of this species. These methods indicated that 57.9% of the sequences showed to be putative toxins unknown in public databases; among them, we pointed out a novel putative toxin named Cryptoxin-1. The recombinant form of this new toxin was able to promote edema in mice footpads with massive neutrophils infiltration, linking this toxin to envenomation symptoms observed in accidents with humans. Our findings may elucidate the role of this toxin in the venom, as well as the possibility to explore other proteins found in this work. (AU) | |
| Processo FAPESP: | 17/13812-4 - Transcriptoma, clonagem, expressão e avaliação das atividades biológicas das principais toxinas do veneno da centopeia Cryptops iheringi |
| Beneficiário: | Lhiri Hanna de Lucca Caetano |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 17/16999-8 - Análise transcriptomica da glândula de veneno da centopeia Cryptops iheringi, expressão heteróloga das principais toxinas e estudo de suas atividades biológicas |
| Beneficiário: | Geraldo Santana Magalhães |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 13/07467-1 - CeTICS - Centro de Toxinas, Imuno-Resposta e Sinalização Celular |
| Beneficiário: | Hugo Aguirre Armelin |
| Modalidade de apoio: | Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs |