| Texto completo | |
| Autor(es): |
Torres-Obreque, Karin M.
[1]
;
Meneguetti, Giovanna P.
[1, 2]
;
Muso-Cachumba, Jorge J.
[1]
;
Feitosa, Valker A.
[1, 2]
;
Santos, Joao H. P. M.
[1, 3]
;
Ventura, Sonia P. M.
[3]
;
Rangel-Yagui, Carlota O.
[1]
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Biochem & Pharmaceut Technol, Sao Paulo - Brazil
[2] Inst Technol Res IPT, Bionanomfg Ctr, Sao Paulo - Brazil
[3] Univ Aveiro, Dept Chem, CICECO Aveiro Inst Mat, Aveiro - Portugal
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo de Revisão |
| Fonte: | DRUG DISCOVERY TODAY; v. 27, n. 1, p. 65-81, JAN 2022. |
| Citações Web of Science: | 0 |
| Resumo | |
Biological drugs or biopharmaceuticals off patent open a large market for biosimilars and biobetters, follow-on biologics. Biobetters, in particular, are new drugs designed from existing ones with improved properties such as higher selectivity, stability, half-life and/or lower toxicity/immunogenicity. Glycosylation is one of the most used strategies to improve biological drugs, nonetheless bioconjugation is an additional alternative and refers to the covalent attachment of polymers to biological drugs. Extensive research on novel polymers is underway, nonetheless PEGylation is still the best alternative with the longest clinical track record. Innovative trends based on genetic engineering techniques such as fusion proteins and PASylation are also promising. In this review, all these alternatives were explored as well as current market trends, legislation and future perspectives. (AU) | |
| Processo FAPESP: | 16/22065-5 - Pegilação N-terminal de proteínas e purificação por sistemas aquosos bifásicos |
| Beneficiário: | Carlota de Oliveira Rangel Yagui |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 18/25994-2 - Desenvolvimento de novas plataformas de PEGuilação de proteínas com potencial terapêutico com recurso à microfluídica |
| Beneficiário: | João Henrique Picado Madalena Santos |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |