| Full text | |
| Author(s): |
Torres-Obreque, Karin M.
[1]
;
Meneguetti, Giovanna P.
[1, 2]
;
Muso-Cachumba, Jorge J.
[1]
;
Feitosa, Valker A.
[1, 2]
;
Santos, Joao H. P. M.
[1, 3]
;
Ventura, Sonia P. M.
[3]
;
Rangel-Yagui, Carlota O.
[1]
Total Authors: 7
|
| Affiliation: | [1] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Biochem & Pharmaceut Technol, Sao Paulo - Brazil
[2] Inst Technol Res IPT, Bionanomfg Ctr, Sao Paulo - Brazil
[3] Univ Aveiro, Dept Chem, CICECO Aveiro Inst Mat, Aveiro - Portugal
Total Affiliations: 3
|
| Document type: | Review article |
| Source: | DRUG DISCOVERY TODAY; v. 27, n. 1, p. 65-81, JAN 2022. |
| Web of Science Citations: | 0 |
| Abstract | |
Biological drugs or biopharmaceuticals off patent open a large market for biosimilars and biobetters, follow-on biologics. Biobetters, in particular, are new drugs designed from existing ones with improved properties such as higher selectivity, stability, half-life and/or lower toxicity/immunogenicity. Glycosylation is one of the most used strategies to improve biological drugs, nonetheless bioconjugation is an additional alternative and refers to the covalent attachment of polymers to biological drugs. Extensive research on novel polymers is underway, nonetheless PEGylation is still the best alternative with the longest clinical track record. Innovative trends based on genetic engineering techniques such as fusion proteins and PASylation are also promising. In this review, all these alternatives were explored as well as current market trends, legislation and future perspectives. (AU) | |
| FAPESP's process: | 16/22065-5 - N-terminal pegylation of proteins and purification by aqueous two-phase systems |
| Grantee: | Carlota de Oliveira Rangel Yagui |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 18/25994-2 - Development of novel platforms for PEGylation of proteins with therapeutic potential using microfluidics |
| Grantee: | João Henrique Picado Madalena Santos |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |