Th17/Treg Imbalance in Chronic Obstructive Pulmonary Disease: Clinical and Experimental Evidence

Autor(es)

Lourenco, Juliana Dias ^[1] ; Ito, Juliana Tiyaki ^[1] ; Martins, Milton de Arruda ^[1] ; Tiberio, Iolanda de Fatima Lopes Calvo ^[1] ; Lopes, Fernanda Degobbi Tenorio Quirino dos Santos ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med, Lab Expt Therapeut LIM 20, Dept Clin Med, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: FRONTIERS IN IMMUNOLOGY; v. 12, DEC 9 2021.
• Citações Web of Science: 0

Resumo

The imbalance between pro- and anti-inflammatory immune responses mediated by Th17 and Treg cells is deeply involved in the development and progression of inflammation in chronic obstructive pulmonary disease (COPD). Several clinical and experimental studies have described the Th17/Treg imbalance in COPD progression. Due to its importance, many studies have also evaluated the effect of different treatments targeting Th17/Treg cells. However, discrepant results have been observed among different lung compartments, different COPD stages or local and systemic markers. Thus, the data must be carefully examined. In this context, this review explores and summarizes the recent outcomes of Th17/Treg imbalance in COPD development and progression in clinical, experimental and in vitro studies. (AU)

• Processo FAPESP: 19/25374-7 - Efeito do exercício físico na atenuação do desequilíbrio das respostas Th17/Treg em pacientes com Doença Pulmonar Obstrutiva Crônica (DPOC)
• Beneficiário: Fernanda Degobbi Tenorio Quirino dos Santos Lopes
• Modalidade de apoio: Auxílio à Pesquisa - Regular