Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Th17/Treg Imbalance in Chronic Obstructive Pulmonary Disease: Clinical and Experimental Evidence

Full text
Author(s):
Lourenco, Juliana Dias [1] ; Ito, Juliana Tiyaki [1] ; Martins, Milton de Arruda [1] ; Tiberio, Iolanda de Fatima Lopes Calvo [1] ; Lopes, Fernanda Degobbi Tenorio Quirino dos Santos [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Sch Med, Lab Expt Therapeut LIM 20, Dept Clin Med, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Review article
Source: FRONTIERS IN IMMUNOLOGY; v. 12, DEC 9 2021.
Web of Science Citations: 0
Abstract

The imbalance between pro- and anti-inflammatory immune responses mediated by Th17 and Treg cells is deeply involved in the development and progression of inflammation in chronic obstructive pulmonary disease (COPD). Several clinical and experimental studies have described the Th17/Treg imbalance in COPD progression. Due to its importance, many studies have also evaluated the effect of different treatments targeting Th17/Treg cells. However, discrepant results have been observed among different lung compartments, different COPD stages or local and systemic markers. Thus, the data must be carefully examined. In this context, this review explores and summarizes the recent outcomes of Th17/Treg imbalance in COPD development and progression in clinical, experimental and in vitro studies. (AU)

FAPESP's process: 19/25374-7 - Effect of physical exercise in attenuating the imbalance of Th17/Treg responses in patients with Chronic Obstructive Pulmonary Disease (COPD)
Grantee:Fernanda Degobbi Tenorio Quirino dos Santos Lopes
Support Opportunities: Regular Research Grants